loading...

SH3BP2

The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases, and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Full Name

SH3BP2

Function

Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.

Biological Process

Signal transduction

Involvement in disease

Cherubism (CRBM):
An autosomal dominant syndrome characterized by excessive bone degradation of the upper and lower jaws, which often begins around three years of age. It is followed by development of fibrous tissue masses, which causes a characteristic facial swelling.

PTM

Phosphorylated. Phosphorylation at Tyr-448 may stimulate the activity of the LYN kinase (By similarity).

View more

Anti-SH3BP2 antibodies

+ Filters

Loading...

Mouse Anti-SH3BP2 Recombinant Antibody (1E9) (CBMAB-A8088-LY)

Compare

Target: SH3BP2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1E9

Application*: WB, E

Mouse Anti-SH3BP2 Recombinant Antibody (CBXS-4087) (CBMAB-S1344-CQ)

Compare

Target: SH3BP2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXS-4087

Application*: E, IF, WB

Mouse Anti-SH3BP2 Recombinant Antibody (6G12) (CBMAB-0920-CN)

Compare

Target: SH3BP2

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 6G12

Application*: E, M

Mouse Anti-SH3BP2 Recombinant Antibody (1G5) (CBMAB-0919-CN)

Compare

Target: SH3BP2

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 1G5

Application*: E, M

Mouse Anti-SH3BP2 Recombinant Antibody (1B9) (CBMAB-0918-CN)

Compare

Target: SH3BP2

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 1B9

Application*: E, M

Mouse Anti-SH3BP2 Recombinant Antibody (14H6) (CBMAB-0913-CN)

Compare

Target: SH3BP2

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 14H6

Application*: E, M

Mouse Anti-SH3BP2 Recombinant Antibody (10H10) (CBMAB-0912-CN)

Compare

Target: SH3BP2

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 10H10

Application*: E, M

More Infomation

Submit A Review

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Submit A Review

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Hot products

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

online inquiry

Online Inquiry