SH3BP2

The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases, and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Full Name
SH3BP2
Function
Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.
Biological Process
Signal transduction
Involvement in disease
Cherubism (CRBM):
An autosomal dominant syndrome characterized by excessive bone degradation of the upper and lower jaws, which often begins around three years of age. It is followed by development of fibrous tissue masses, which causes a characteristic facial swelling.
PTM
Phosphorylated. Phosphorylation at Tyr-448 may stimulate the activity of the LYN kinase (By similarity).
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Anti-SH3BP2 antibodies

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Mouse Anti-SH3BP2 Recombinant Antibody (1E9) (CBMAB-A8088-LY)

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Target: SH3BP2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1E9
Application*: WB, E
Datasheet SDS

Mouse Anti-SH3BP2 Recombinant Antibody (CBXS-4087) (CBMAB-S1344-CQ)

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Target: SH3BP2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-4087
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-SH3BP2 Recombinant Antibody (6G12) (CBMAB-0920-CN)

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Target: SH3BP2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 6G12
Application*: E, M
Datasheet SDS

Mouse Anti-SH3BP2 Recombinant Antibody (1G5) (CBMAB-0919-CN)

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Target: SH3BP2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 1G5
Application*: E, M
Datasheet SDS

Mouse Anti-SH3BP2 Recombinant Antibody (1B9) (CBMAB-0918-CN)

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Target: SH3BP2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 1B9
Application*: E, M
Datasheet SDS

Mouse Anti-SH3BP2 Recombinant Antibody (14H6) (CBMAB-0913-CN)

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Target: SH3BP2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 14H6
Application*: E, M
Datasheet SDS

Mouse Anti-SH3BP2 Recombinant Antibody (10H10) (CBMAB-0912-CN)

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Target: SH3BP2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 10H10
Application*: E, M
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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