SH3BP5

Full Name
SH3-domain binding protein 5 (BTK-associated)
Function
Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (PubMed:26506309, PubMed:30217979).
Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.
Biological Process
Biological Process intracellular signal transductionManual Assertion Based On ExperimentIDA:MGI
Biological Process negative regulation of protein tyrosine kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasmic vesicle membrane
Mitochondrion
Colocalizes with RAB11A on cytoplasmic vesicle membranes.
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Anti-SH3BP5 antibodies

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Mouse Anti-SH3BP5 Recombinant Antibody (2B3) (CBMAB-A8092-LY)

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Target: SH3BP5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2B3
Application*: WB, E
Datasheet SDS

Mouse Anti-SH3BP5 Recombinant Antibody (1D5) (CBMAB-A8091-LY)

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Target: SH3BP5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1D5
Application*: WB, E
Datasheet SDS

Mouse Anti-SH3BP5 Recombinant Antibody (CBXS-2741) (CBMAB-S5492-CQ)

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Target: SH3BP5
Host: Mouse
Specificity: Human
Clone: CBXS-2741
Application*: E, WB
Datasheet SDS

Mouse Anti-SH3BP5 Recombinant Antibody (CBXS-4388) (CBMAB-S1631-CQ)

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Target: SH3BP5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-4388
Application*: E, IF, P, WB
Datasheet SDS
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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