SH3BP5

Full Name

SH3-domain binding protein 5 (BTK-associated)

Function

Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (PubMed:26506309, PubMed:30217979).
Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.

Biological Process

Biological Process intracellular signal transductionManual Assertion Based On ExperimentIDA:MGI
Biological Process negative regulation of protein tyrosine kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cytoplasmic vesicle membrane
Mitochondrion
Colocalizes with RAB11A on cytoplasmic vesicle membranes.

Anti-SH3BP5 antibodies

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-SH3BP5 Recombinant Antibody (2B3) (CBMAB-A8092-LY)

Datasheet

SDS

Target: SH3BP5

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2B3

Application*: WB, E

Mouse Anti-SH3BP5 Recombinant Antibody (1D5) (CBMAB-A8091-LY)

Datasheet

SDS

Target: SH3BP5

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1D5

Application*: WB, E

Mouse Anti-SH3BP5 Recombinant Antibody (CBXS-2741) (CBMAB-S5492-CQ)

Datasheet

SDS

Target: SH3BP5

Host: Mouse

Specificity: Human

Clone: CBXS-2741

Application*: E, WB

Mouse Anti-SH3BP5 Recombinant Antibody (CBXS-4388) (CBMAB-S1631-CQ)

Datasheet

SDS

Target: SH3BP5

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXS-4388

Application*: E, IF, P, WB

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)