Mouse Anti-SH3BP5 Recombinant Antibody (CBXS-2741) (CBMAB-S5492-CQ)

Name: Mouse Anti-SH3BP5 Recombinant Antibody (CBXS-2741)
SKU: CBMAB-S5492-CQ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

CBXS-2741

Application

ELISA, WB

Immunogen

SH3BP5 (NP_004835, 4aa-112aa) partial recombinant protein with GST tag

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

SH3-domain binding protein 5 (BTK-associated)

Entrez Gene ID

9467

UniProt ID

O60239

Alternative Names

SH3 Domain Binding Protein 5; SH3 Domain-Binding Protein That Preferentially Associates With BTK; SH3-Domain Binding Protein 5 (BTK-Associated); SH3BP-5; SAB; SH3 Domain-Binding Protein 5; SH3 Binding Protein;

Function

Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (PubMed:26506309, PubMed:30217979).
Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.

Biological Process

Biological Process intracellular signal transductionManual Assertion Based On ExperimentIDA:MGI
Biological Process negative regulation of protein tyrosine kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cytoplasmic vesicle membrane
Mitochondrion
Colocalizes with RAB11A on cytoplasmic vesicle membranes.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Mouse Anti-SH3BP5 Recombinant Antibody (CBXS-4388) (CAT#: CBMAB-S1631-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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