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Mouse Anti-SH3BP5 Recombinant Antibody (1D5) (CBMAB-A8091-LY)

The product is antibody recognizes SH3BP5. The antibody 1D5 immunoassay techniques such as: WB, ELISA.
See all SH3BP5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1D5
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
SH3BP5 (NP_004835, 4 a.a. ~ 112 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
SH3-domain binding protein 5 (BTK-associated)
Entrez Gene ID
9467
UniProt ID
O60239
Alternative Names
SAB
Function
Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (PubMed:26506309, PubMed:30217979).
Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.
Biological Process
Biological Process intracellular signal transductionManual Assertion Based On ExperimentIDA:MGI
Biological Process negative regulation of protein tyrosine kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasmic vesicle membrane
Mitochondrion
Colocalizes with RAB11A on cytoplasmic vesicle membranes.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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