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Mouse Anti-SH3BP5 Recombinant Antibody (CBXS-4388) (CBMAB-S1631-CQ)

This product is a mouse antibody that recognizes SH3BP5. The antibody CBXS-4388 can be used for immunoassay techniques such as: ELISA, IF, IHC-P, WB.
See all SH3BP5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4388
Antibody Isotype
IgG1, κ
Application
ELISA, IF, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SH3-domain binding protein 5 (BTK-associated)
Entrez Gene ID
9467
UniProt ID
O60239
Alternative Names
SH3 Domain Binding Protein 5; SH3 Domain-Binding Protein That Preferentially Associates With BTK; SH3-Domain Binding Protein 5 (BTK-Associated); SH3BP-5; SAB; SH3 Domain-Binding Protein 5; SH3 Binding Protein;
Function
Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (PubMed:26506309, PubMed:30217979).
Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.
Biological Process
Biological Process intracellular signal transductionManual Assertion Based On ExperimentIDA:MGI
Biological Process negative regulation of protein tyrosine kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasmic vesicle membrane
Mitochondrion
Colocalizes with RAB11A on cytoplasmic vesicle membranes.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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