SH3GL3
The characteristics of the interaction between SH3GL3 and huntingtin and the colocalization of the two proteins suggest that SH3GL3 could be involved in the selective neuronal cell death in HD.
Full Name
SH3-domain GRB2-like 3
Function
Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity).
Biological Process
Biological Process central nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of clathrin-dependent endocytosisIEA:Ensembl
Biological Process positive regulation of neuron differentiationIEA:Ensembl
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process synaptic vesicle uncoatingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of clathrin-dependent endocytosisIEA:Ensembl
Biological Process positive regulation of neuron differentiationIEA:Ensembl
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process synaptic vesicle uncoatingManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Early endosome membrane
Associated with postsynaptic endosomes in hippocampal neurons. Associated with presynaptic endosomes in olfactory neurons.
Early endosome membrane
Associated with postsynaptic endosomes in hippocampal neurons. Associated with presynaptic endosomes in olfactory neurons.
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Anti-SH3GL3 antibodies
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Target: SH3GL3
Host: Rabbit
Specificity: Mouse
Clone: CBXS-0346
Application*: WB
More Infomation
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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