SH3GL3

The characteristics of the interaction between SH3GL3 and huntingtin and the colocalization of the two proteins suggest that SH3GL3 could be involved in the selective neuronal cell death in HD.

SH3-domain GRB2-like 3

Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity).

Biological Process central nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of clathrin-dependent endocytosisIEA:Ensembl
Biological Process positive regulation of neuron differentiationIEA:Ensembl
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process synaptic vesicle uncoatingManual Assertion Based On ExperimentIBA:GO_Central

Cytoplasm
Early endosome membrane
Associated with postsynaptic endosomes in hippocampal neurons. Associated with presynaptic endosomes in olfactory neurons.