SIGLEC8

Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs, are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM, and a motif homologous to one identified in signaling lymphocyte activation molecule that mediates an association with SLAM-associated protein.
Full Name
sialic acid binding Ig-like lectin 8
Function
Putative adhesion molecule that mediates sialic-acid dependent binding to red blood cells (PubMed:10856141, PubMed:10625619).
Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface (PubMed:10625619).
Recognizes simultaneously epitopes having a terminal N-acetylneuraminic acid (sialic acid) and an underlying 6-O-sulfated galactose. Preferentially binds to Gal-6-sulfated sialyl-Lewis X glycan epitopes (PubMed:27357658).
Biological Process
Biological Process cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Membrane
Topology
Extracellular: 17-363
Helical: 364-384
Cytoplasmic: 385-499
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Anti-SIGLEC8 antibodies

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Mouse Anti-SIGLEC8 Recombinant Antibody (CBXS-3127) (CBMAB-S5870-CQ)

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Target: SIGLEC8
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXS-3127
Application*: E, WB
Datasheet SDS

Recombinant Mouse Anti-SIGLEC8 Recombinant Antibody (7C9) (CBMAB-XB1036-YC)

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Target: SIGLEC8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7C9
Application*: E, F, IP
Datasheet SDS

Mouse Anti-SIGLEC8 Recombinant Antibody (CBXS-0373) (CBMAB-S3336-CQ)

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Target: SIGLEC8
Host: Mouse
Specificity: Human
Clone: CBXS-0373
Application*: WB, IC, P, C, E
Datasheet SDS

Human Anti-SIGLEC8 Recombinant Antibody (CBXS-3572) (CBMAB-S0387-CQ)

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Target: SIGLEC8
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3572
Application*: F
Datasheet SDS

Mouse Anti-SIGLEC8 Recombinant Antibody (CBXS-1949) (CBMAB-S0147-CQ)

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Target: SIGLEC8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-1949
Application*: F
Datasheet SDS

Human Recombinant SIGLEC8 protein, ECD, His Tag (V2LY-0526-LY6807)

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Target: SIGLEC8
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-363
Tag: His Tag
Datasheet SDS

Human Recombinant SIGLEC8 protein, ECD, hFc Tag (V2LY-0526-LY6806)

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Target: SIGLEC8
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-363
Tag: hFc Tag
Datasheet SDS

Mouse Anti-SIGLEC8 Recombinant Antibody (CBT4447) (V2LY-0625-LY1641)

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Target: SIGLEC8
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT4447
Application*: WB, IH, F
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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