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Mouse Anti-SIGLEC8 Recombinant Antibody (CBT4447) (V2LY-0625-LY1641)


See all SIGLEC8 antibodies
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Tested Data
Mouse Anti-SIGLEC8 Recombinant Antibody (CBT4447) (V2LY-0625-LY1641) in ELISA
Mouse Anti-SIGLEC8 Recombinant Antibody (CBT4447) (V2LY-0625-LY1641) in ELISA
Mouse Anti-SIGLEC8 Recombinant Antibody (CBT4447) (V2LY-0625-LY1641) in WB
Mouse Anti-SIGLEC8 Recombinant Antibody (CBT4447) (V2LY-0625-LY1641) in WB
Mouse Anti-SIGLEC8 Recombinant Antibody (CBT4447) (V2LY-0625-LY1641) in WB
Mouse Anti-SIGLEC8 Recombinant Antibody (CBT4447) (V2LY-0625-LY1641) in WB
Mouse Anti-SIGLEC8 Recombinant Antibody (CBT4447) (V2LY-0625-LY1641) in WB
Mouse Anti-SIGLEC8 Recombinant Antibody (CBT4447) (V2LY-0625-LY1641) in WB
Mouse Anti-SIGLEC8 Recombinant Antibody (CBT4447) (V2LY-0625-LY1641) in FC
Mouse Anti-SIGLEC8 Recombinant Antibody (CBT4447) (V2LY-0625-LY1641) in FC
Mouse Anti-SIGLEC8 Recombinant Antibody (CBT4447) (V2LY-0625-LY1641) in IHC
Mouse Anti-SIGLEC8 Recombinant Antibody (CBT4447) (V2LY-0625-LY1641) in IHC
Mouse Anti-SIGLEC8 Recombinant Antibody (CBT4447) (V2LY-0625-LY1641) in IHC
Mouse Anti-SIGLEC8 Recombinant Antibody (CBT4447) (V2LY-0625-LY1641) in IHC

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT4447
Antibody Isotype
IgG2b
Application
WB, IHC, FC

Basic Information

Immunogen
Purified recombinant fragment of human SIGLEC8 (AA: extra 17-216) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
sialic acid binding Ig-like lectin 8
Entrez Gene ID
27181
Function
Putative adhesion molecule that mediates sialic-acid dependent binding to red blood cells (PubMed:10856141, PubMed:10625619).
Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface (PubMed:10625619).
Recognizes simultaneously epitopes having a terminal N-acetylneuraminic acid (sialic acid) and an underlying 6-O-sulfated galactose. Preferentially binds to Gal-6-sulfated sialyl-Lewis X glycan epitopes (PubMed:27357658).
Biological Process
Biological Process cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Membrane
Topology
Extracellular: 17-363
Helical: 364-384
Cytoplasmic: 385-499
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For research use only. Not intended for any clinical use.

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