SLA
Full Name
Src-like-adaptor
Function
Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
Biological Process
Biological Process cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process innate immune responseManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of signal transductionIEA:InterPro
Biological Process transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process innate immune responseManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of signal transductionIEA:InterPro
Biological Process transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Endosome
Colocalizes with endosomes.
Endosome
Colocalizes with endosomes.
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Anti-SLA antibodies
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Target: SLA
Host: Mouse
Specificity: Human
Clone: CBXS-2110
Application*: WB, IP, IF, E
Target: SLA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2A1
Application*: WB, E
Target: SLA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXS-4324
Application*: E, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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