SLC22A2

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption. [provided by RefSeq]

Full Name

solute carrier family 22 (organic cation transporter), member 2

Function

Mediates tubular uptake of organic compounds from circulation. Mediates the transport of prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may be involved in their renal excretion (PubMed:11907186).
Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamine, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity.

Biological Process

Biological Process activation of cysteine-type endopeptidase activity involved in apoptotic processISS:ARUK-UCL
Biological Process amine transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process amino acid import across plasma membraneManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process body fluid secretionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process choline transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process dopamine uptakeManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process export across plasma membraneManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process histamine uptakeManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process L-alpha-amino acid transmembrane transportManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process L-arginine import across plasma membraneManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process neurotransmitter transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process norepinephrine uptakeManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process organic cation transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process positive regulation of gene expressionISS:ARUK-UCL
Biological Process purine-containing compound transmembrane transportTAS:Reactome
Biological Process serotonin uptakeManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process toxin transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process transport across blood-brain barrier2 PublicationsNAS:ARUK-UCL
Biological Process xenobiotic transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process xenobiotic transport across blood-brain barrier1 PublicationNAS:ARUK-UCL

Cellular Location

Membrane