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SLC25A24

This gene encodes a carrier protein that transports ATP-Mg exchanging it for phosphate. Multiple transcript variants encoding different isoforms have been found for this gene.
Full Name
SLC25A24
Function
Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress-induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitochondrial matrix, and thereby buffering calcium levels in the mitochondrial matrix.
Biological Process
Biological Process ATP transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to calcium ionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to oxidative stressManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mitochondrial transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of cell deathManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Mitochondrion inner membrane
Involvement in disease
Fontaine progeroid syndrome (FPS):
An autosomal dominant progeroid disorder characterized by prenatal and postnatal growth retardation, decreased subcutaneous fat tissue, wrinkled skin, an aged appearance since birth, an abnormal scalp hair pattern, sparse hair, hypoplastic distal phalanges with hypoplastic nails, a widely open anterior fontanel, facial dysmorphisms, and craniosynostosis. Early death is observed in some patients.
Topology
Mitochondrial intermembrane: 1-197
Helical: 198-215
Mitochondrial matrix: 216-252
Helical: 253-272
Mitochondrial intermembrane: 273-295
Helical: 296-309
Mitochondrial matrix: 310-345
Helical: 346-365
Mitochondrial intermembrane: 366-388
Helical: 389-406
Mitochondrial matrix: 407-445
Helical: 446-465
Mitochondrial intermembrane: 466-477

Anti-SLC25A24 antibodies

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Target: SLC25A24
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3G2
Application*: IP, M, WB
Target: SLC25A24
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-2861
Application*: E, WB
Target: SLC25A24
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3666
Application*: IP, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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