Mouse Anti-SLC25A24 Recombinant Antibody (CBXS-2861) (CBMAB-S5611-CQ)

Name: Mouse Anti-SLC25A24 Recombinant Antibody (CBXS-2861)
SKU: CBMAB-S5611-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-2861

Application

ELISA, WB

Immunogen

Partial recombinant corresponding to aa1-67 from human SLC25A24 (NP_037518) with GST tag

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

SLC25A24

Introduction

This gene encodes a carrier protein that transports ATP-Mg exchanging it for phosphate. Multiple transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

29957

UniProt ID

Q6NUK1

Alternative Names

Solute Carrier Family 25 Member 24; Solute Carrier Family 25 (Mitochondrial Carrier; Phosphate Carrier), Member 24; Mitochondrial Ca(2+)-Dependent Solute Carrier Protein 1; Small Calcium-Binding Mitochondrial Carrier Protein 1; Mitochondrial ATP-Mg/Pi Carrier Protein 1; APC1; Calcium-Binding Mitochondrial Carrier Protein SCaMC-1;

Function

Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress-induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitochondrial matrix, and thereby buffering calcium levels in the mitochondrial matrix.

Biological Process

Biological Process ATP transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to calcium ionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to oxidative stressManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mitochondrial transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of cell deathManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Mitochondrion inner membrane

Involvement in disease

Fontaine progeroid syndrome (FPS):
An autosomal dominant progeroid disorder characterized by prenatal and postnatal growth retardation, decreased subcutaneous fat tissue, wrinkled skin, an aged appearance since birth, an abnormal scalp hair pattern, sparse hair, hypoplastic distal phalanges with hypoplastic nails, a widely open anterior fontanel, facial dysmorphisms, and craniosynostosis. Early death is observed in some patients.

Topology

Mitochondrial intermembrane: 1-197
Helical: 198-215
Mitochondrial matrix: 216-252
Helical: 253-272
Mitochondrial intermembrane: 273-295
Helical: 296-309
Mitochondrial matrix: 310-345
Helical: 346-365
Mitochondrial intermembrane: 366-388
Helical: 389-406
Mitochondrial matrix: 407-445
Helical: 446-465
Mitochondrial intermembrane: 466-477

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-SLC25A24 Monoclonal Antibody (3G2) (CAT#: CBMAB-0111-LY)

Mouse Anti-SLC25A24 Recombinant Antibody (CBXS-3666) (CAT#: CBMAB-S0945-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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