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Mouse Anti-SLC25A24 Monoclonal Antibody (3G2) (CBMAB-0111-LY)

This product is mouse monoclonal antibody recognizes SLC25A24 of human. The antibody 3G2 immunoassay techniques such as: IP, MA, WB.
See all SLC25A24 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3G2
Antibody Isotype
IgG1
Application
IP, MA, WB

Basic Information

Immunogen
Recombinant peptide (Full Length)
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
SLC25A24
Introduction
This gene encodes a carrier protein that transports ATP-Mg exchanging it for phosphate. Multiple transcript variants encoding different isoforms have been found for this gene. Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels.
Entrez Gene ID
29957
UniProt ID
Q6NUK1
Alternative Names
APC1; DKFZp586G0123
Function
Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress-induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitochondrial matrix, and thereby buffering calcium levels in the mitochondrial matrix.
Biological Process
Biological Process ATP transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to calcium ionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to oxidative stressManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mitochondrial transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of cell deathManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Mitochondrion inner membrane
Involvement in disease
Fontaine progeroid syndrome (FPS):
An autosomal dominant progeroid disorder characterized by prenatal and postnatal growth retardation, decreased subcutaneous fat tissue, wrinkled skin, an aged appearance since birth, an abnormal scalp hair pattern, sparse hair, hypoplastic distal phalanges with hypoplastic nails, a widely open anterior fontanel, facial dysmorphisms, and craniosynostosis. Early death is observed in some patients.
Topology
Mitochondrial intermembrane: 1-197
Helical: 198-215
Mitochondrial matrix: 216-252
Helical: 253-272
Mitochondrial intermembrane: 273-295
Helical: 296-309
Mitochondrial matrix: 310-345
Helical: 346-365
Mitochondrial intermembrane: 366-388
Helical: 389-406
Mitochondrial matrix: 407-445
Helical: 446-465
Mitochondrial intermembrane: 466-477
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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