SLC27A3

This gene belongs to a family of integral membrane proteins and encodes a protein that is involved in lipid metabolism. The increased expression of this gene in human neural stem cells derived from induced pluripotent stem cells suggests that it plays an important role in early brain development. Naturally occurring mutations in this gene are associated with autism spectrum disorders. Alternative splicing results in multiple transcript variants.

Full Name

solute carrier family 27 (fatty acid transporter), member 3

Function

Mainly functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates (PubMed:23936004).
Can mediate the levels of long-chain fatty acids (LCFA) in the cell by facilitating their transport across membranes (By similarity).

Biological Process

Biological Process fatty acid transportManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process long-chain fatty acid metabolic processManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Mitochondrion membrane

Topology

Helical: 3-23