SLITRK4

This gene encodes a transmembrane protein belonging to the the SLITRK family. These family members include two N-terminal leucine-rich repeat domains similar to those found in the axonal growth-controlling protein SLIT, as well as C-terminal regions similar to neurotrophin receptors. Studies of an homologous protein in mouse suggest that this family member functions to suppress neurite outgrowth. Alternative splicing results in multiple transcript variants.

Full Name

SLIT And NTRK Like Family Member 4

Function

It is involved in synaptogenesis and promotes synapse differentiation (PubMed:27812321).
Suppresses neurite outgrowth (By similarity).

Biological Process

Biological Process axonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of synapse assemblyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of presynapse assemblyIEA:InterPro
Biological Process regulation of synapse organizationManual Assertion Based On ExperimentIDA:SynGO

Cellular Location

Membrane
Cell membrane

Topology

Extracellular: 19-618
Helical: 619-639
Cytoplasmic: 640-837