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SLITRK4

This gene encodes a transmembrane protein belonging to the the SLITRK family. These family members include two N-terminal leucine-rich repeat domains similar to those found in the axonal growth-controlling protein SLIT, as well as C-terminal regions similar to neurotrophin receptors. Studies of an homologous protein in mouse suggest that this family member functions to suppress neurite outgrowth. Alternative splicing results in multiple transcript variants.

Full Name

SLIT And NTRK Like Family Member 4

Function

It is involved in synaptogenesis and promotes synapse differentiation (PubMed:27812321).
Suppresses neurite outgrowth (By similarity).

Biological Process

Biological Process axonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of synapse assemblyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of presynapse assemblyIEA:InterPro
Biological Process regulation of synapse organizationManual Assertion Based On ExperimentIDA:SynGO

Cellular Location

Membrane
Cell membrane

Topology

Extracellular: 19-618
Helical: 619-639
Cytoplasmic: 640-837

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Anti-SLITRK4 antibodies

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Mouse Anti-SLITRK4 Recombinant Antibody (CBXS-1769) (CBMAB-S4586-CQ)

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Target: SLITRK4

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXS-1769

Application*: WB

Human Recombinant SLITRK4 protein, His Tag (V2LY-0526-LY6873)

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Target: SLITRK4

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-616

Tag: His Tag

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For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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