SMC6L1

Full Name

structural maintenance of chromosomes 6

Function

Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541).

Biological Process

Biological Process cellular response to DNA damage stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular senescenceManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process double-strand break repair via homologous recombinationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of chromosome segregationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein sumoylation1 PublicationIC:ComplexPortal
Biological Process regulation of telomere maintenance1 PublicationIC:ComplexPortal
Biological Process telomere maintenance via recombinationManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Nucleus
Nucleus speckle
Chromosome
Nucleus, PML body
Chromosome, telomere
Colocalizes with SMC5 on the X-Y chromosome pair within the sex vesicle during late pachytene/diplotene (By similarity).
Localizes to PML nuclear bodies in ALT cell lines (PubMed:17589526).
Associates with chromatin (PubMed:25931565).
Accumulates with RAD18 and the SLF1-SLF2 complex at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner (PubMed:25931565).
Localizes in interchromatin granule clusters (PubMed:11408570).

PTM

Phosphorylated.
Sumoylated by NSMCE2/MMS21.
Ubiquitinated.
(Microbial infection) SMC5-SMC6 complex is degraded by the activity of Hepatitis B X protein.