SMYD3
This gene encodes a histone methyltransferase which functions in RNA polymerase II complexes by an interaction with a specific RNA helicase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Full Name
SET And MYND Domain Containing 3
Function
Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation (PubMed:15235609, PubMed:22419068).
Also methylates 'Lys-5' of histone H4 (PubMed:22419068).
Plays an important role in transcriptional activation as a member of an RNA polymerase complex (PubMed:15235609).
Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences (PubMed:15235609).
Also methylates 'Lys-5' of histone H4 (PubMed:22419068).
Plays an important role in transcriptional activation as a member of an RNA polymerase complex (PubMed:15235609).
Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences (PubMed:15235609).
Biological Process
Biological Process cellular response to dexamethasone stimulusIEA:Ensembl
Biological Process establishment of protein localizationIEA:Ensembl
Biological Process histone lysine methylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process myotube cell developmentIEA:Ensembl
Biological Process negative regulation of protein kinase activityIEA:Ensembl
Biological Process nucleosome assemblyIEA:Ensembl
Biological Process positive regulation of peptidyl-serine phosphorylationIEA:Ensembl
Biological Process positive regulation of transcription by RNA polymerase IIIEA:Ensembl
Biological Process establishment of protein localizationIEA:Ensembl
Biological Process histone lysine methylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process myotube cell developmentIEA:Ensembl
Biological Process negative regulation of protein kinase activityIEA:Ensembl
Biological Process nucleosome assemblyIEA:Ensembl
Biological Process positive regulation of peptidyl-serine phosphorylationIEA:Ensembl
Biological Process positive regulation of transcription by RNA polymerase IIIEA:Ensembl
Cellular Location
Cytoplasm
Nucleus
Mainly cytoplasmic when cells are arrested at G0/G1. Accumulates in the nucleus at S phase and G2/M.
Nucleus
Mainly cytoplasmic when cells are arrested at G0/G1. Accumulates in the nucleus at S phase and G2/M.
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Anti-SMYD3 antibodies
Products List
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CompareTarget: SMYD3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: D2Q4V
Application*: WB
Target: SMYD3
Host: Mouse
Specificity: Human
Clone: CBXS-2095
Application*: WB, IP, IF, E
Target: SMYD3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBXS-1454
Application*: WB, IP
Target: SMYD3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBXS-1272
Application*: WB, IP, P, F, IF
Target: SMYD3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1271
Application*: WB, IP, P, IF
Target: SMYD3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-0587
Application*: P, IP
Target: SMYD3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-0586
Application*: P, IP, WB
Target: SMYD3
Host: Rabbit
Specificity: Human, Monkey
Clone: CBXS-5373
Application*: WB
Target: SMYD3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3881
Application*: E, WB, IH
Target: SMYD3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3600
Application*: WB, IH, IP, P
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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