SMYD3

This gene encodes a histone methyltransferase which functions in RNA polymerase II complexes by an interaction with a specific RNA helicase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Full Name
SET And MYND Domain Containing 3
Function
Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation (PubMed:15235609, PubMed:22419068).
Also methylates 'Lys-5' of histone H4 (PubMed:22419068).
Plays an important role in transcriptional activation as a member of an RNA polymerase complex (PubMed:15235609).
Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences (PubMed:15235609).
Biological Process
Biological Process cellular response to dexamethasone stimulusIEA:Ensembl
Biological Process establishment of protein localizationIEA:Ensembl
Biological Process histone lysine methylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process myotube cell developmentIEA:Ensembl
Biological Process negative regulation of protein kinase activityIEA:Ensembl
Biological Process nucleosome assemblyIEA:Ensembl
Biological Process positive regulation of peptidyl-serine phosphorylationIEA:Ensembl
Biological Process positive regulation of transcription by RNA polymerase IIIEA:Ensembl
Cellular Location
Cytoplasm
Nucleus
Mainly cytoplasmic when cells are arrested at G0/G1. Accumulates in the nucleus at S phase and G2/M.
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Anti-SMYD3 antibodies

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Rabbit Anti-SMYD3 Recombinant Antibody (D2Q4V) (CBMAB-CP2523-LY)

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Target: SMYD3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: D2Q4V
Application*: WB
Datasheet SDS

Mouse Anti-SMYD3 Recombinant Antibody (CBXS-2095) (CBMAB-S4860-CQ)

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Target: SMYD3
Host: Mouse
Specificity: Human
Clone: CBXS-2095
Application*: WB, IP, IF, E
Datasheet SDS

Rabbit Anti-SMYD3 Recombinant Antibody (CBXS-1454) (CBMAB-S4311-CQ)

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Target: SMYD3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBXS-1454
Application*: WB, IP
Datasheet SDS

Rabbit Anti-SMYD3 Recombinant Antibody (CBXS-1272) (CBMAB-S4131-CQ)

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Target: SMYD3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBXS-1272
Application*: WB, IP, P, F, IF
Datasheet SDS

Rabbit Anti-SMYD3 Recombinant Antibody (CBXS-1271) (CBMAB-S4130-CQ)

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Target: SMYD3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1271
Application*: WB, IP, P, IF
Datasheet SDS

Mouse Anti-SMYD3 Recombinant Antibody (CBXS-0587) (CBMAB-S3529-CQ)

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Target: SMYD3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-0587
Application*: P, IP
Datasheet SDS

Mouse Anti-SMYD3 Recombinant Antibody (CBXS-0586) (CBMAB-S3528-CQ)

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Target: SMYD3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-0586
Application*: P, IP, WB
Datasheet SDS

Rabbit Anti-SMYD3 Recombinant Antibody (CBXS-5373) (CBMAB-S2586-CQ)

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Target: SMYD3
Host: Rabbit
Specificity: Human, Monkey
Clone: CBXS-5373
Application*: WB
Datasheet SDS

Mouse Anti-SMYD3 Recombinant Antibody (CBXS-3881) (CBMAB-S1150-CQ)

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Target: SMYD3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3881
Application*: E, WB, IH
Datasheet SDS

Mouse Anti-SMYD3 Recombinant Antibody (CBXS-3600) (CBMAB-S0886-CQ)

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Target: SMYD3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3600
Application*: WB, IH, IP, P
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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