SMYD3

This gene encodes a histone methyltransferase which functions in RNA polymerase II complexes by an interaction with a specific RNA helicase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

SET And MYND Domain Containing 3

Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation (PubMed:15235609, PubMed:22419068).
Also methylates 'Lys-5' of histone H4 (PubMed:22419068).
Plays an important role in transcriptional activation as a member of an RNA polymerase complex (PubMed:15235609).
Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences (PubMed:15235609).

Biological Process cellular response to dexamethasone stimulusIEA:Ensembl
Biological Process establishment of protein localizationIEA:Ensembl
Biological Process histone lysine methylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process myotube cell developmentIEA:Ensembl
Biological Process negative regulation of protein kinase activityIEA:Ensembl
Biological Process nucleosome assemblyIEA:Ensembl
Biological Process positive regulation of peptidyl-serine phosphorylationIEA:Ensembl
Biological Process positive regulation of transcription by RNA polymerase IIIEA:Ensembl

Cytoplasm
Nucleus
Mainly cytoplasmic when cells are arrested at G0/G1. Accumulates in the nucleus at S phase and G2/M.