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Rabbit Anti-SMYD3 Recombinant Antibody (CBXS-5373) (CBMAB-S2586-CQ)

This product is a rabbit antibody that recognizes SMYD3. The antibody CBXS-5373 can be used for immunoassay techniques such as: WB.
See all SMYD3 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Monkey
Clone
CBXS-5373
Application
WB

Basic Information

Specificity
Human, Monkey
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SET And MYND Domain Containing 3
Introduction
This gene encodes a histone methyltransferase which functions in RNA polymerase II complexes by an interaction with a specific RNA helicase. Multiple transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
Human64754
Monkey703402
UniProt ID
HumanQ9H7B4
MonkeyH9ETM0
Alternative Names
SET And MYND Domain Containing 3; Zinc Finger MYND Domain-Containing Protein 1; SET And MYND Domain-Containing Protein 3; Zinc Finger, MYND Domain Containing 1; EC 2.1.1.43; ZNFN3A1; ZMYND1;
Function
Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation (PubMed:15235609, PubMed:22419068).
Also methylates 'Lys-5' of histone H4 (PubMed:22419068).
Plays an important role in transcriptional activation as a member of an RNA polymerase complex (PubMed:15235609).
Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences (PubMed:15235609).
Biological Process
Biological Process cellular response to dexamethasone stimulusIEA:Ensembl
Biological Process establishment of protein localizationIEA:Ensembl
Biological Process histone lysine methylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process myotube cell developmentIEA:Ensembl
Biological Process negative regulation of protein kinase activityIEA:Ensembl
Biological Process nucleosome assemblyIEA:Ensembl
Biological Process positive regulation of peptidyl-serine phosphorylationIEA:Ensembl
Biological Process positive regulation of transcription by RNA polymerase IIIEA:Ensembl
Cellular Location
Cytoplasm
Nucleus
Mainly cytoplasmic when cells are arrested at G0/G1. Accumulates in the nucleus at S phase and G2/M.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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