Mouse Anti-SMYD3 Recombinant Antibody (CBXS-3881) (CBMAB-S1150-CQ)

Name: Mouse Anti-SMYD3 Recombinant Antibody (CBXS-3881)
SKU: CBMAB-S1150-CQ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

CBXS-3881

Application

ELISA, WB, IHC

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

SET And MYND Domain Containing 3

Introduction

This gene encodes a histone methyltransferase which functions in RNA polymerase II complexes by an interaction with a specific RNA helicase. Multiple transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

64754

UniProt ID

Q9H7B4

Alternative Names

SET And MYND Domain Containing 3; Zinc Finger MYND Domain-Containing Protein 1; SET And MYND Domain-Containing Protein 3; Zinc Finger, MYND Domain Containing 1; EC 2.1.1.43; ZNFN3A1; ZMYND1;

Function

Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation (PubMed:15235609, PubMed:22419068).
Also methylates 'Lys-5' of histone H4 (PubMed:22419068).
Plays an important role in transcriptional activation as a member of an RNA polymerase complex (PubMed:15235609).
Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences (PubMed:15235609).

Biological Process

Biological Process cellular response to dexamethasone stimulusIEA:Ensembl
Biological Process establishment of protein localizationIEA:Ensembl
Biological Process histone lysine methylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process myotube cell developmentIEA:Ensembl
Biological Process negative regulation of protein kinase activityIEA:Ensembl
Biological Process nucleosome assemblyIEA:Ensembl
Biological Process positive regulation of peptidyl-serine phosphorylationIEA:Ensembl
Biological Process positive regulation of transcription by RNA polymerase IIIEA:Ensembl

Cellular Location

Cytoplasm
Nucleus
Mainly cytoplasmic when cells are arrested at G0/G1. Accumulates in the nucleus at S phase and G2/M.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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