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SOX1

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. In mice, a similar protein regulates the gamma-crystallin genes and is essential for lens development.

Full Name

SRY-Box 1

Function

Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).

Biological Process

Biological Process anatomical structure morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to leukemia inhibitory factorIEA:Ensembl
Biological Process chromatin organization1 PublicationNAS:UniProtKB
Biological Process forebrain neuron developmentIEA:Ensembl
Biological Process interneuron migrationISS:UniProtKB
Biological Process lens morphogenesis in camera-type eyeIEA:Ensembl
Biological Process negative regulation of transcription by RNA polymerase IIISS:UniProtKB
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of oligodendrocyte differentiationISS:UniProtKB
Biological Process ventral spinal cord interneuron specificationIEA:Ensembl

Cellular Location

Nucleus

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Anti-SOX1 antibodies

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Human Anti-SOX1 Recombinant Antibody (CBXS-3569) (CBMAB-S6286-CQ)

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Target: SOX1

Host: Human

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-3569

Application*: F

Human SOX1 ELISA Kit (V2LY-0626-LY2842)

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Target: SOX1

Sensitivity: 0.109 ng/mL

Detection Range: 2-70 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Human

Assay Type: Sandwich

Reactivity: Human

Mouse Anti-SOX1 Recombinant Antibody (CBXS-3419) (CBMAB-S6153-CQ)

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Target: SOX1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: CBXS-3419

Application*: WB

Mouse Anti-SOX1 (AA 242-379) Recombinant Antibody (CBXS-4702) (CBMAB-S1933-CQ)

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Target: SOX1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-4702

Application*: WB

Rabbit Anti-SOX1 Recombinant Antibody (CBXS-1520) (CBMAB-S0408-CQ)

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Target: SOX1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Human

Clone: CBXS-1520

Application*: WB, P, IF

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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