SOX1

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. In mice, a similar protein regulates the gamma-crystallin genes and is essential for lens development.

Full Name

SRY-Box 1

Function

Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).

Biological Process

Biological Process anatomical structure morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to leukemia inhibitory factorIEA:Ensembl
Biological Process chromatin organization1 PublicationNAS:UniProtKB
Biological Process forebrain neuron developmentIEA:Ensembl
Biological Process interneuron migrationISS:UniProtKB
Biological Process lens morphogenesis in camera-type eyeIEA:Ensembl
Biological Process negative regulation of transcription by RNA polymerase IIISS:UniProtKB
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of oligodendrocyte differentiationISS:UniProtKB
Biological Process ventral spinal cord interneuron specificationIEA:Ensembl

Cellular Location

Nucleus