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STC2

This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers. [provided by RefSeq]

Full Name

stanniocalcin 2

Function

Has an anti-hypocalcemic action on calcium and phosphate homeostasis.

Biological Process

Biological Process cellular calcium ion homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to hypoxiaIEA:Ensembl
Biological Process decidualizationIEA:Ensembl
Biological Process embryo implantationIEA:Ensembl
Biological Process endoplasmic reticulum unfolded protein responseIEA:Ensembl
Biological Process negative regulation of gene expressionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of multicellular organism growthIEA:Ensembl
Biological Process regulation of hormone biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of store-operated calcium entryIEA:Ensembl
Biological Process response to oxidative stressIEA:Ensembl
Biological Process response to peptide hormoneIEA:Ensembl
Biological Process response to vitamin DIEA:Ensembl

Cellular Location

Secreted

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Anti-STC2 antibodies

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Mouse Anti-STC2 Recombinant Antibody (CF411) (CBMAB-FT104LY)

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Target: STC2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse

Clone: CF411

Application*: ELISA, WB, IF, IHC

Mouse Anti-STC2 Recombinant Antibody (2B11) (CBMAB-A8668-LY)

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Target: STC2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human, Rat

Clone: 2B11

Application*: WB, E

Rat Anti-STC2 Recombinant Antibody (CBXS-3397) (CBMAB-S6131-CQ)

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Target: STC2

Host: Rat

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXS-3397

Application*: E, WB

Mouse Anti-STC2 Recombinant Antibody (CBXS-2992) (CBMAB-S5738-CQ)

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Target: STC2

Host: Mouse

Antibody Isotype: IgA, κ

Specificity: Human

Clone: CBXS-2992

Application*: E, WB

Rat Anti-STC2 Recombinant Antibody (CBXS-1788) (CBMAB-S4604-CQ)

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Target: STC2

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBXS-1788

Application*: WB

Rat Anti-STC2 Recombinant Antibody (CBXS-1787) (CBMAB-S4603-CQ)

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Target: STC2

Host: Rat

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXS-1787

Application*: WB

Rat Anti-STC2 (AA 25-302) Recombinant Antibody (CBXS-0769) (CBMAB-S3697-CQ)

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Target: STC2

Host: Rat

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXS-0769

Application*: E, WB

Mouse Anti-STC2 Recombinant Antibody (CBXS-0768) (CBMAB-S3696-CQ)

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Target: STC2

Host: Mouse

Antibody Isotype: IgA, κ

Specificity: Human

Clone: CBXS-0768

Application*: WB

Mouse Anti-STC2 Recombinant Antibody (CBXS-0767) (CBMAB-S3695-CQ)

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Target: STC2

Host: Mouse

Antibody Isotype: IgA, κ

Specificity: Human

Clone: CBXS-0767

Application*: WB

Mouse Anti-STC2 Recombinant Antibody (CBXS-4379) (CBMAB-S1622-CQ)

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Target: STC2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human, Rat

Clone: CBXS-4379

Application*: WB, IP, E

Mouse Anti-STC2 Recombinant Antibody (CBXS-5702) (CBMAB-S0570-CQ)

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Target: STC2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: CBXS-5702

Application*: E, WB, IH, IF

Human STC2 ELISA Kit (V2LY-0626-LY5282)

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Target: STC2

Sensitivity: 0.0093 ng/mL

Detection Range: 0.02-4.5 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Human

Assay Type: Sandwich

Reactivity: Human

Human Recombinant STC2 protein, Biotin Conjugated, His Tag (V2LY-0526-LY6985)

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Target: STC2

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-302

Tag: His Tag

Human Recombinant STC2 protein, His Tag (V2LY-0526-LY6984)

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Target: STC2

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-302

Tag: His Tag

Human Recombinant STC2 protein, hFc Tag (V2LY-0526-LY6983)

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Target: STC2

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-302

Tag: hFc Tag

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Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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