SUPT6H

SUPT6H (SPT6 Homolog, Histone Chaperone) is a Protein Coding gene. Diseases associated with SUPT6H include Chromosome 17Q11.2 Deletion Syndrome, 1.4-Mb. Among its related pathways are Formation of HIV-1 elongation complex containing HIV-1 Tat and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity.

SPT6 Homolog, Histone Chaperone

Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A.

Biological Process blastocyst formationIEA:Ensembl
Biological Process mRNA processingIEA:UniProtKB-KW
Biological Process mRNA transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process mRNA transportIEA:UniProtKB-KW
Biological Process negative regulation of histone H3-K27 methylationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process nucleosome organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of transcription elongation by RNA polymerase IIManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of isotype switchingISS:UniProtKB
Biological Process regulation of mRNA export from nucleusISS:UniProtKB
Biological Process regulation of mRNA processingISS:UniProtKB
Biological Process regulation of muscle cell differentiationISS:UniProtKB
Biological Process RNA splicingIEA:UniProtKB-KW
Biological Process transcription elongation by RNA polymerase II promoterManual Assertion Based On ExperimentIBA:GO_Central

Nucleus