SYAP1

This protein plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' after growth factor stimulation.

Full Name

SYAP1

Function

Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' after growth factor stimulation (PubMed:23300339).

Biological Process

Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process cellular response to epidermal growth factor stimulusIMP:UniProtKB1 Publication
Biological Process cellular response to insulin stimulusIMP:UniProtKB1 Publication
Biological Process cellular response to insulin-like growth factor stimulusIMP:UniProtKB1 Publication
Biological Process cellular response to platelet-derived growth factor stimulusIMP:UniProtKB1 Publication
Biological Process positive regulation of fat cell differentiationIMP:UniProtKB1 Publication
Biological Process positive regulation of protein serine/threonine kinase activityIMP:UniProtKB1 Publication
Biological Process regulation of short-term neuronal synaptic plasticityIBA:GO_Central1 Publication
Biological Process TORC2 signalingIMP:UniProtKB1 Publication

Cellular Location

Cytoplasm, perinuclear region
Golgi apparatus
Perikaryon
Cell projection, axon
Cell projection, dendrite
Cell projection, growth cone
Presynaptic cell membrane
Postsynaptic cell membrane
Membrane
Localizes to cholinergic neuromuscular junctions and in actin-rich growth cone regions (By similarity).
Membrane-associated in a epidermal growth factor (EGF)-dependent manner (PubMed:23300339).

PTM

Phosphorylated. Phosphorylation increases in a mTORC2-mediated manner in response to epidermal growth factor (EGF) stimulation.