SYNJ2

Synaptojanin-2 is a ubiquitously expressed inositol polyphosphate 5-phosphatase (Malecz et al., 2000 [PubMed 11084340]).[supplied by OMIM

SYNJ2

Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis.

Biological Process brain developmentIBA:GO_Central1 Publication
Biological Process inositol phosphate dephosphorylationIBA:GO_Central1 Publication
Biological Process membrane organizationTAS:Reactome
Biological Process phosphatidylinositol biosynthetic processTAS:Reactome
Biological Process phosphatidylinositol dephosphorylationIBA:GO_Central1 Publication
Biological Process synaptic vesicle endocytosisIBA:GO_Central1 Publication

Cytoplasm
Cell membrane
Membrane raft
Presynapse
Cytoplasm, cytoskeleton
Localizes at presynapse terminals in brain and at bundles of microtubules surrounding the nucleus in the elongating spermatids corresponding to the manchette (By similarity).
Translocates from the cytoplasm to membrane ruffles in a RAC1-dependent manner (PubMed:11084340).