Tcf21

TCF21 encodes a transcription factor of the basic helix-loop-helix family. The TCF21 product is mesoderm specific, and expressed in embryonic epicardium, mesenchyme-derived tissues of lung, gut, gonad, and both mesenchymal and glomerular epithelial cells in the kidney.

Full Name

Transcription Factor 21

Function

Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types.

Biological Process

Biological Process branching involved in ureteric bud morphogenesisISS:BHF-UCL
Biological Process branchiomeric skeletal muscle developmentISS:UniProtKB
Biological Process bronchiole developmentISS:UniProtKB
Biological Process developmental processIBA:GO_Central1 Publication
Biological Process diaphragm developmentISS:UniProtKB
Biological Process embryonic digestive tract morphogenesisISS:UniProtKB
Biological Process epithelial cell differentiationISS:UniProtKB
Biological Process gland developmentISS:UniProtKB
Biological Process glomerulus developmentISS:UniProtKB
Biological Process kidney developmentISS:BHF-UCL
Biological Process lung alveolus developmentISS:UniProtKB
Biological Process lung morphogenesisISS:UniProtKB
Biological Process lung vasculature developmentISS:UniProtKB
Biological Process metanephric glomerular capillary formationISS:UniProtKB
Biological Process metanephric mesenchymal cell differentiationISS:UniProtKB
Biological Process morphogenesis of a branching structureISS:BHF-UCL
Biological Process negative regulation of androgen receptor signaling pathwayISS:BHF-UCL
Biological Process negative regulation of transcription by RNA polymerase IIIDA:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase IIISS:UniProtKB
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Biological Process reproductive structure developmentISS:UniProtKB
Biological Process respiratory system developmentISS:UniProtKB
Biological Process roof of mouth developmentISS:UniProtKB
Biological Process Sertoli cell differentiationISS:UniProtKB
Biological Process sex determinationISS:UniProtKB
Biological Process spleen developmentISS:UniProtKB
Biological Process ureteric bud developmentISS:BHF-UCL
Biological Process vasculature developmentISS:BHF-UCL

Cellular Location

Nucleus