TFAP4

Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988 [PubMed 2833704]; Hu et al., 1990 [PubMed 2123466]).[supplied by OMIM

Full Name

transcription factor AP-4 (activating enhancer binding protein 4)

Function

Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.

Biological Process

Biological Process cellular response to dexamethasone stimulusSource:Ensembl
Biological Process DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorSource:UniProtKB1 Publication
Biological Process negative regulation by host of viral transcriptionSource:UniProtKB2 Publications
Biological Process negative regulation of cell population proliferationSource:UniProtKB1 Publication
Biological Process negative regulation of cyclin-dependent protein serine/threonine kinase activitySource:UniProtKB1 Publication
Biological Process negative regulation of DNA bindingSource:UniProtKB2 Publications
Biological Process negative regulation of DNA-templated transcriptionSource:UniProtKB3 Publications
Biological Process negative regulation of gene expressionSource:Ensembl
Biological Process positive regulation by host of viral transcriptionSource:UniProtKB1 Publication
Biological Process positive regulation of apoptotic processSource:UniProtKB1 Publication
Biological Process positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwaySource:Ensembl
Biological Process positive regulation of DNA-templated transcriptionSource:UniProtKB1 Publication
Biological Process protein-containing complex assemblySource:UniProtKB1 Publication
Biological Process regulation of mitotic cell cycle phase transitionSource:UniProtKB1 Publication
Biological Process regulation of transcription by RNA polymerase IISource:GO_Central1 Publication

Cellular Location

Nucleus