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Mouse Anti-TFAP4 Recombinant Antibody (6B1) (CBMAB-A9031-LY)

The product is antibody recognizes TFAP4. The antibody 6B1 immunoassay techniques such as: WB, ELISA.
See all TFAP4 antibodies
Published Data
Fig.1 Expression of AP4 protein after c-Myc activation.
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Fig.2 Western blots of c-Myc, AP4, and actin expressed in the indicated cells.
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Fig.3 Expression patterns and levels of AP4 in RPE cells and RPE stable cell clones.
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Fig.4 Serum is required for AP4-induced cellular senescence.
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Fig.5 TFAP4isdegradedduringtheG2phaseofthe cell cycle.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
6B1
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
TFAP4 (NP_003214, 93 a.a. ~ 192 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
transcription factor AP-4 (activating enhancer binding protein 4)
Introduction
Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988 [PubMed 2833704]; Hu et al., 1990 [PubMed 2123466]).[supplied by OMIM
Entrez Gene ID
7023
UniProt ID
Q01664
Alternative Names
AP-4; bHLHc41
Function
Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.
Biological Process
Biological Process cellular response to dexamethasone stimulusSource:Ensembl
Biological Process DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorSource:UniProtKB1 Publication
Biological Process negative regulation by host of viral transcriptionSource:UniProtKB2 Publications
Biological Process negative regulation of cell population proliferationSource:UniProtKB1 Publication
Biological Process negative regulation of cyclin-dependent protein serine/threonine kinase activitySource:UniProtKB1 Publication
Biological Process negative regulation of DNA bindingSource:UniProtKB2 Publications
Biological Process negative regulation of DNA-templated transcriptionSource:UniProtKB3 Publications
Biological Process negative regulation of gene expressionSource:Ensembl
Biological Process positive regulation by host of viral transcriptionSource:UniProtKB1 Publication
Biological Process positive regulation of apoptotic processSource:UniProtKB1 Publication
Biological Process positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwaySource:Ensembl
Biological Process positive regulation of DNA-templated transcriptionSource:UniProtKB1 Publication
Biological Process protein-containing complex assemblySource:UniProtKB1 Publication
Biological Process regulation of mitotic cell cycle phase transitionSource:UniProtKB1 Publication
Biological Process regulation of transcription by RNA polymerase IISource:GO_Central1 Publication
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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