TGFA
Tgfa acts as an EGF receptor ligand and inhibits apoptosis that results from epithelial detachment from the extracellular matrix.
Full Name
Transforming Growth Factor Alpha
Function
TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
Biological Process
Biological Process angiogenesisSource:Ensembl
Biological Process epidermal growth factor receptor signaling pathwaySource:GO_Central1 Publication
Biological Process ERBB2-EGFR signaling pathwaySource:MGI1 Publication
Biological Process hepatocyte proliferationSource:Ensembl
Biological Process intracellular signal transductionSource:GO_Central1 Publication
Biological Process mammary gland alveolus developmentSource:Ensembl
Biological Process negative regulation of apoptotic processSource:Ensembl
Biological Process positive regulation of cell divisionSource:UniProtKB-KW
Biological Process positive regulation of cell population proliferationSource:GO_Central1 Publication
Biological Process positive regulation of epidermal growth factor-activated receptor activitySource:HGNC-UCL1 Publication
Biological Process positive regulation of epithelial cell proliferationSource:HGNC-UCL1 Publication
Biological Process positive regulation of MAP kinase activitySource:HGNC-UCL1 Publication
Biological Process positive regulation of mitotic nuclear divisionSource:HGNC-UCL1 Publication
Biological Process response to xenobiotic stimulusSource:Ensembl
Biological Process wound healingSource:Ensembl
Biological Process epidermal growth factor receptor signaling pathwaySource:GO_Central1 Publication
Biological Process ERBB2-EGFR signaling pathwaySource:MGI1 Publication
Biological Process hepatocyte proliferationSource:Ensembl
Biological Process intracellular signal transductionSource:GO_Central1 Publication
Biological Process mammary gland alveolus developmentSource:Ensembl
Biological Process negative regulation of apoptotic processSource:Ensembl
Biological Process positive regulation of cell divisionSource:UniProtKB-KW
Biological Process positive regulation of cell population proliferationSource:GO_Central1 Publication
Biological Process positive regulation of epidermal growth factor-activated receptor activitySource:HGNC-UCL1 Publication
Biological Process positive regulation of epithelial cell proliferationSource:HGNC-UCL1 Publication
Biological Process positive regulation of MAP kinase activitySource:HGNC-UCL1 Publication
Biological Process positive regulation of mitotic nuclear divisionSource:HGNC-UCL1 Publication
Biological Process response to xenobiotic stimulusSource:Ensembl
Biological Process wound healingSource:Ensembl
Cellular Location
Transforming growth factor alpha
Secreted, extracellular space
Protransforming growth factor alpha
Cell membrane
Secreted, extracellular space
Protransforming growth factor alpha
Cell membrane
Topology
Extracellular: 24-98
Helical: 99-124
Cytoplasmic: 125-160
Helical: 99-124
Cytoplasmic: 125-160
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Anti-TGFA antibodies
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Target: TGFA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat, Human, Mouse, Cattle
Clone: SPM357
Application*: IF, IC, F
Target: TGFA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat, Human, Mouse, Cattle
Clone: MF9
Application*: WB, F, IC, IF, IP, C
Target: TGFA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat, Human, Mouse, Cattle
Clone: CBYJT-2759
Application*: WB
Target: Tgfa
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat
Clone: CBYJT-2758
Application*: WB
Target: TGFA
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat, Mouse
Clone: CBYJT-2757
Application*: WB, IP, IF
Target: TGFA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rabbit, Zebrafish
Clone: TG86
Application*: F, E, IC, IF, IP, P, C, MC
Target: TGFA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rabbit, Zebrafish
Clone: P/T1
Application*: F, E, IC, IF, IP, P, C, MC
Target: TGFA
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human, Rabbit, Zebrafish
Clone: 1E8-G6
Application*: F, E, IC, IF, IP, P, C, MC
Target: TGFA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Dog, Rat, Hamster
Clone: 213-4.4
Application*: IC, IF, IH, C, P
Target: TGFA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: TGFA/1119
Application*: F, P, IF, MC
Target: TGFA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: TFGFa-1
Application*: P, IF, IC
Target: TGFA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1E8-269
Application*: C, E, P
Target: TGFA
Host: Mouse
Specificity: Human
Clone: CBFYE-1668
Application*: WB, IC, P, C, E
Target: TGFA
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human, Rabbit, Zebrafish, Sheep
Clone: SPM542
Application*: F, IC, IF, C, P, IP
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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