Mouse Anti-TGFA Recombinant Antibody (TFGFa-1) (CBMAB-T1966-YJ)

Name: Mouse Anti-TGFA Recombinant Antibody (TFGFa-1)
SKU: CBMAB-T1966-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

TFGFa-1

Application

IHC-P, IF, ICC

Immunogen

Recombinant human full-length TGF protein was used as the immunogen for the TGF alpha antibody

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, 100 μg/mL BSA

Preservative

0.05% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Transforming Growth Factor Alpha

Introduction

TGFA is a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. TGFA may act as either a transmembrane-bound ligand or a soluble ligand. TGFA has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate.

Entrez Gene ID

7039

UniProt ID

P01135

Alternative Names

Transforming Growth Factor Alpha; Protransforming Growth Factor Alpha; Transforming Growth Factor, Alpha; TGF-Alpha; TFGA

Function

TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.

Biological Process

Biological Process angiogenesisSource:Ensembl
Biological Process epidermal growth factor receptor signaling pathwaySource:GO_Central1 Publication
Biological Process ERBB2-EGFR signaling pathwaySource:MGI1 Publication
Biological Process hepatocyte proliferationSource:Ensembl
Biological Process intracellular signal transductionSource:GO_Central1 Publication
Biological Process mammary gland alveolus developmentSource:Ensembl
Biological Process negative regulation of apoptotic processSource:Ensembl
Biological Process positive regulation of cell divisionSource:UniProtKB-KW
Biological Process positive regulation of cell population proliferationSource:GO_Central1 Publication
Biological Process positive regulation of epidermal growth factor-activated receptor activitySource:HGNC-UCL1 Publication
Biological Process positive regulation of epithelial cell proliferationSource:HGNC-UCL1 Publication
Biological Process positive regulation of MAP kinase activitySource:HGNC-UCL1 Publication
Biological Process positive regulation of mitotic nuclear divisionSource:HGNC-UCL1 Publication
Biological Process response to xenobiotic stimulusSource:Ensembl
Biological Process wound healingSource:Ensembl

Cellular Location

Transforming growth factor alpha
Secreted, extracellular space
Protransforming growth factor alpha
Cell membrane

Topology

Extracellular: 24-98
Helical: 99-124
Cytoplasmic: 125-160

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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