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Mouse Anti-TGFA Recombinant Antibody (1E8-G6) (CBMAB-T1969-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TGFA (Transforming Growth Factor Alpha). The antibody can be used for immunoassay techniques, such as FC, ELISA, ICC, IF, IP, IHC-P, IHC-Fr, CyTOF.
See all TGFA antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rabbit, Zebrafish
Clone
1E8-G6
Antibody Isotype
IgM, κ
Application
FC, ELISA, ICC, IF, IP, IHC-P, IHC-Fr, CyTOF

Basic Information

Immunogen
A 10-amino acid synthetic peptide (aa 34-43; PPVAAAVVSH) from human TGF alpha
Specificity
Human, Rabbit, Zebrafish
Antibody Isotype
IgM, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 34-43

Target

Full Name
Transforming Growth Factor Alpha
Introduction
TGFA is a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. TGFA may act as either a transmembrane-bound ligand or a soluble ligand. TGFA has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate.
Entrez Gene ID
Human7039
Rabbit100009482
Zebrafish100034402
UniProt ID
HumanP01135
RabbitP98138
ZebrafishI3ISP4
Alternative Names
Transforming Growth Factor Alpha; Protransforming Growth Factor Alpha; Transforming Growth Factor, Alpha; TGF-Alpha; TFGA
Function
TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
Biological Process
Biological Process angiogenesisSource:Ensembl
Biological Process epidermal growth factor receptor signaling pathwaySource:GO_Central1 Publication
Biological Process ERBB2-EGFR signaling pathwaySource:MGI1 Publication
Biological Process hepatocyte proliferationSource:Ensembl
Biological Process intracellular signal transductionSource:GO_Central1 Publication
Biological Process mammary gland alveolus developmentSource:Ensembl
Biological Process negative regulation of apoptotic processSource:Ensembl
Biological Process positive regulation of cell divisionSource:UniProtKB-KW
Biological Process positive regulation of cell population proliferationSource:GO_Central1 Publication
Biological Process positive regulation of epidermal growth factor-activated receptor activitySource:HGNC-UCL1 Publication
Biological Process positive regulation of epithelial cell proliferationSource:HGNC-UCL1 Publication
Biological Process positive regulation of MAP kinase activitySource:HGNC-UCL1 Publication
Biological Process positive regulation of mitotic nuclear divisionSource:HGNC-UCL1 Publication
Biological Process response to xenobiotic stimulusSource:Ensembl
Biological Process wound healingSource:Ensembl
Cellular Location
Transforming growth factor alpha
Secreted, extracellular space
Protransforming growth factor alpha
Cell membrane
Topology
Extracellular: 24-98
Helical: 99-124
Cytoplasmic: 125-160
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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