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Mouse Anti-Tgfa Recombinant Antibody (MF9) (CBMAB-T1977-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Tgfa (Transforming Growth Factor Alpha). The antibody can be used for immunoassay techniques, such as WB, FC, ICC, IF, IP, IHC-Fr.
See all Tgfa antibodies
Published Data
Fig.1 Transforming growth factor (TGF)-α immunostain in the epithelium of subjects with CF.
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Fig.2 Western blots of HB-EGF and TGFα using total protein extracts from the lesion area of the corpus callosum at 5 DPL.
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Summary

Host Animal
Mouse
Specificity
Rat, Human, Mouse, Cattle
Clone
MF9
Antibody Isotype
IgG1, κ
Application
WB, FC, ICC, IF, IP, IHC-Fr

Basic Information

Immunogen
A 17-amino acid synthetic peptide from the carboxyl-terminus of rat TGFalpha
Specificity
Rat, Human, Mouse, Cattle
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
C-terminus

Target

Full Name
Transforming Growth Factor Alpha
Introduction
Tgfa acts as an EGF receptor ligand and inhibits apoptosis that results from epithelial detachment from the extracellular matrix.
Entrez Gene ID
Human7039
Mouse21802
Rat24827
Cattle540388
UniProt ID
HumanP01135
MouseP48030
RatP01134
CattleF1MWF2
Alternative Names
TGFAA; RATTGFAA
Function
TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
Biological Process
Biological Process angiogenesisSource:Ensembl
Biological Process epidermal growth factor receptor signaling pathwaySource:GO_Central1 Publication
Biological Process ERBB2-EGFR signaling pathwaySource:MGI1 Publication
Biological Process hepatocyte proliferationSource:Ensembl
Biological Process intracellular signal transductionSource:GO_Central1 Publication
Biological Process mammary gland alveolus developmentSource:Ensembl
Biological Process negative regulation of apoptotic processSource:Ensembl
Biological Process positive regulation of cell divisionSource:UniProtKB-KW
Biological Process positive regulation of cell population proliferationSource:GO_Central1 Publication
Biological Process positive regulation of epidermal growth factor-activated receptor activitySource:HGNC-UCL1 Publication
Biological Process positive regulation of epithelial cell proliferationSource:HGNC-UCL1 Publication
Biological Process positive regulation of MAP kinase activitySource:HGNC-UCL1 Publication
Biological Process positive regulation of mitotic nuclear divisionSource:HGNC-UCL1 Publication
Biological Process response to xenobiotic stimulusSource:Ensembl
Biological Process wound healingSource:Ensembl
Cellular Location
Transforming growth factor alpha
Secreted, extracellular space
Protransforming growth factor alpha
Cell membrane
Topology
Extracellular: 24-98
Helical: 99-124
Cytoplasmic: 125-160
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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