TGS1

TGS1 (Trimethylguanosine Synthase 1) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Gene Expression. Gene Ontology (GO) annotations related to TGS1 include methyltransferase activity and RNA trimethylguanosine synthase activity.

Full Name

Trimethylguanosine Synthase 1

Function

Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m7G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.

Biological Process

Biological Process 7-methylguanosine cap hypermethylationSource:BHF-UCL1 Publication
Biological Process 7-methylguanosine RNA cappingSource:InterPro
Biological Process ribonucleoprotein complex biogenesisSource:BHF-UCL1 Publication
Biological Process spliceosomal snRNP assemblySource:Reactome

Cellular Location

Cytoplasm
Nucleus, Cajal body
Nucleus, nucleolus
A 90 kDa isoform is found in the nucleus while a 55 kDa isoform is found in the cytoplasm and colocalizes with the tubulin network.