Sign in or Register   Sign in or Register
  |  

Mouse Anti-TGS1 Recombinant Antibody (K121) (CBMAB-2109CQ)

This product is a mouse monoclonal antibody that recognizes TGS1. The antibody K121 can be used for immunoassay techniques such as: IHC-P, IF.
See all TGS1 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
K121
Antibody Isotype
IgG
Application
IHC-P, IF

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Trimethylguanosine Synthase 1
Introduction
The 2,2,7-trimethylguanosine cap structure is found on the 5' end of small nuclear RNAs and small nucleolar RNAs. Capping of RNAs is an important requirement for RNA transport and splicing processes. Uncapped RNAs are rapidly degraded by the 5′ exoribonuclease enzyme. 2,2,7-trimethylguanosine capping may play a role in the expression of viral RNAs.
Entrez Gene ID
Human96764
Mouse116940
Rat312947
UniProt ID
HumanQ96RS0
MouseQ923W1
RatP85107
Alternative Names
PIMT; PIPMT; NCOA6IP
Function
Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m7G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.
Biological Process
Biological Process 7-methylguanosine cap hypermethylationSource:BHF-UCL1 Publication
Biological Process 7-methylguanosine RNA cappingSource:InterPro
Biological Process ribonucleoprotein complex biogenesisSource:BHF-UCL1 Publication
Biological Process spliceosomal snRNP assemblySource:Reactome
Cellular Location
Cytoplasm
Nucleus, Cajal body
Nucleus, nucleolus
A 90 kDa isoform is found in the nucleus while a 55 kDa isoform is found in the cytoplasm and colocalizes with the tubulin network.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-TGS1 Recombinant Antibody (K121)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare