Sign in or Register   Sign in or Register
  |  

Mouse Anti-TGS1 Recombinant Antibody (CBYJT-2881) (CBMAB-T2112-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TGS1 (Trimethylguanosine Synthase 1). The antibody can be used for immunoassay techniques, such as ELISA.
See all TGS1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2881
Antibody Isotype
IgG1, κ
Application
ELISA

Basic Information

Immunogen
Full length recombinant corresponding to aa1-142 from human NCOA6IP (AAH11999) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-142

Target

Full Name
Trimethylguanosine Synthase 1
Introduction
TGS1 (Trimethylguanosine Synthase 1) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Gene Expression. Gene Ontology (GO) annotations related to TGS1 include methyltransferase activity and RNA trimethylguanosine synthase activity.
Entrez Gene ID
96764
UniProt ID
Q96RS0
Alternative Names
Trimethylguanosine Synthase 1; PRIP-Interacting Protein With Methyltransferase Motif; Nuclear Receptor Coactivator 6-Interacting Protein; Hepatocellular Carcinoma-Associated Antigen 137; Cap-Specific Guanine-N2 Methyltransferase; CLL-Associated Antigen KW-2; NCOA6IP; PIPMT
Function
Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m7G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.
Biological Process
Biological Process 7-methylguanosine cap hypermethylationSource:BHF-UCL1 Publication
Biological Process 7-methylguanosine RNA cappingSource:InterPro
Biological Process ribonucleoprotein complex biogenesisSource:BHF-UCL1 Publication
Biological Process spliceosomal snRNP assemblySource:Reactome
Cellular Location
Cytoplasm
Nucleus, Cajal body
Nucleus, nucleolus
A 90 kDa isoform is found in the nucleus while a 55 kDa isoform is found in the cytoplasm and colocalizes with the tubulin network.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-TGS1 Recombinant Antibody (CBYJT-2881)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare