Mouse Anti-TGS1 Recombinant Antibody (CBYJT-2881) (CBMAB-T2112-YJ)

Name: Mouse Anti-TGS1 Recombinant Antibody (CBYJT-2881)
SKU: CBMAB-T2112-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

CBYJT-2881

Application

ELISA

Immunogen

Full length recombinant corresponding to aa1-142 from human NCOA6IP (AAH11999) with GST tag. MW of the GST tag alone is 26kD

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 1-142

More Infomation

Target

Full Name

Trimethylguanosine Synthase 1

Introduction

TGS1 (Trimethylguanosine Synthase 1) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Gene Expression. Gene Ontology (GO) annotations related to TGS1 include methyltransferase activity and RNA trimethylguanosine synthase activity.

Entrez Gene ID

96764

UniProt ID

Q96RS0

Alternative Names

Trimethylguanosine Synthase 1; PRIP-Interacting Protein With Methyltransferase Motif; Nuclear Receptor Coactivator 6-Interacting Protein; Hepatocellular Carcinoma-Associated Antigen 137; Cap-Specific Guanine-N2 Methyltransferase; CLL-Associated Antigen KW-2; NCOA6IP; PIPMT

Function

Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m7G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.

Biological Process

Biological Process 7-methylguanosine cap hypermethylationSource:BHF-UCL1 Publication
Biological Process 7-methylguanosine RNA cappingSource:InterPro
Biological Process ribonucleoprotein complex biogenesisSource:BHF-UCL1 Publication
Biological Process spliceosomal snRNP assemblySource:Reactome

Cellular Location

Cytoplasm
Nucleus, Cajal body
Nucleus, nucleolus
A 90 kDa isoform is found in the nucleus while a 55 kDa isoform is found in the cytoplasm and colocalizes with the tubulin network.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Mouse Anti-TGS1 Recombinant Antibody (K121) (CAT#: CBMAB-2109CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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