THRSP
The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism. [provided by RefSeq]
Full Name
thyroid hormone responsive (SPOT14 homolog, rat)
Function
Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA (By similarity).
May function as transcriptional coactivator. May modulate the transcription factor activity of THRB.
May function as transcriptional coactivator. May modulate the transcription factor activity of THRB.
Biological Process
Biological Process lipid metabolic processSource:ProtInc1 Publication
Biological Process regulation of lipid biosynthetic processSource:UniProtKB
Biological Process regulation of triglyceride biosynthetic processSource:Ensembl
Biological Process response to bacteriumSource:Ensembl
Biological Process regulation of lipid biosynthetic processSource:UniProtKB
Biological Process regulation of triglyceride biosynthetic processSource:Ensembl
Biological Process response to bacteriumSource:Ensembl
Cellular Location
Nucleus
Cytoplasm
Cytoplasm
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Anti-THRSP antibodies
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Target: THRSP
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2F8
Application*: IH, E
Target: THRSP
Host: Mouse
Specificity: Human
Clone: CBXS-0929
Application*: WB, IC, P, C, E
Target: THRSP
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-3041
Application*: E, IH
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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