THRSP

The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism. [provided by RefSeq]

thyroid hormone responsive (SPOT14 homolog, rat)

Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA (By similarity).
May function as transcriptional coactivator. May modulate the transcription factor activity of THRB.

Biological Process lipid metabolic processSource:ProtInc1 Publication
Biological Process regulation of lipid biosynthetic processSource:UniProtKB
Biological Process regulation of triglyceride biosynthetic processSource:Ensembl
Biological Process response to bacteriumSource:Ensembl

Nucleus
Cytoplasm