TIAM2

This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

TIAM2 Gene(Protein Coding) T Cell Lymphoma Invasion And Metastasis 2

Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity).
Activates specifically RAC1, but not CDC42 and RHOA.

Biological Process activation of GTPase activitySource:GO_Central1 Publication
Biological Process positive regulation of axonogenesisSource:GO_Central1 Publication
Biological Process regulation of small GTPase mediated signal transductionSource:Reactome
Biological Process small GTPase mediated signal transductionSource:GO_Central1 Publication

Cytoplasm
Cell projection, lamellipodium
Cell projection, filopodium
Cell projection, growth cone
Cell projection, neuron projection
Perikaryon

Phosphorylated on serine and threonine residues. Phosphorylated on Thr-1648 by Rho-kinase. Its phosphorylation by Rho-kinase inhibits its guanine nucleotide exchange activity, its interaction with MAP1A, MAP1B, PARP1 and YWHAE and reduces its ability to promote neurite growth (By similarity).