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TIAM2

This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Full Name
TIAM2 Gene(Protein Coding) T Cell Lymphoma Invasion And Metastasis 2
Function
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity).
Activates specifically RAC1, but not CDC42 and RHOA.
Biological Process
Biological Process activation of GTPase activitySource:GO_Central1 Publication
Biological Process positive regulation of axonogenesisSource:GO_Central1 Publication
Biological Process regulation of small GTPase mediated signal transductionSource:Reactome
Biological Process small GTPase mediated signal transductionSource:GO_Central1 Publication
Cellular Location
Cytoplasm
Cell projection, lamellipodium
Cell projection, filopodium
Cell projection, growth cone
Cell projection, neuron projection
Perikaryon
PTM
Phosphorylated on serine and threonine residues. Phosphorylated on Thr-1648 by Rho-kinase. Its phosphorylation by Rho-kinase inhibits its guanine nucleotide exchange activity, its interaction with MAP1A, MAP1B, PARP1 and YWHAE and reduces its ability to promote neurite growth (By similarity).
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Anti-TIAM2 antibodies

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Mouse Anti-TIAM2 Recombinant Antibody (3C1) (CBMAB-A9092-LY)

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Target: TIAM2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3C1
Application*: WB, E
Datasheet SDS

Mouse Anti-TIAM2 Recombinant Antibody (1C10) (CBMAB-A9091-LY)

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Target: TIAM2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1C10
Application*: WB, E
Datasheet SDS

Mouse Anti-TIAM2 Recombinant Antibody (CBYJT-3117) (CBMAB-T2385-YJ)

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Target: TIAM2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat, Mouse
Clone: CBYJT-3117
Application*: WB, IP, IF, E
Datasheet SDS

Rabbit Anti-TIAM2 Recombinant Antibody (CBYJT-3116) (CBMAB-T2384-YJ)

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Target: TIAM2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Rat, Mouse
Clone: CBYJT-3116
Application*: WB, P, F, IC, IF
Datasheet SDS

Mouse Anti-TIAM2 Recombinant Antibody (CBYJT-3115) (CBMAB-T2383-YJ)

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Target: TIAM2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-3115
Application*: SE, E, WB
Datasheet SDS

Mouse Anti-TIAM2 Recombinant Antibody (CBYJT-3114) (CBMAB-T2382-YJ)

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Target: TIAM2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-3114
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-TIAM2 Recombinant Antibody (CBYJT-3113) (CBMAB-T2381-YJ)

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Target: TIAM2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-3113
Application*: E, WB
Datasheet SDS

TIAM2 Matched Antibody Pair (1205) (APMAB-1205LY)

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Target: TIAM2
Specificity: Human
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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