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Mouse Anti-TIAM2 Recombinant Antibody (1C10) (CBMAB-A9091-LY)

The product is antibody recognizes TIAM2. The antibody 1C10 immunoassay techniques such as: WB, ELISA.
See all TIAM2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1C10
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
TIAM2 (NP_001010927, 527 a.a. ~ 624 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TIAM2 Gene(Protein Coding) T Cell Lymphoma Invasion And Metastasis 2
Introduction
This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq]
Entrez Gene ID
26230
UniProt ID
Q8IVF5
Alternative Names
FLJ41865; STEF
Function
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity).
Activates specifically RAC1, but not CDC42 and RHOA.
Biological Process
Biological Process activation of GTPase activitySource:GO_Central1 Publication
Biological Process positive regulation of axonogenesisSource:GO_Central1 Publication
Biological Process regulation of small GTPase mediated signal transductionSource:Reactome
Biological Process small GTPase mediated signal transductionSource:GO_Central1 Publication
Cellular Location
Cytoplasm
Cell projection, lamellipodium
Cell projection, filopodium
Cell projection, growth cone
Cell projection, neuron projection
Perikaryon
PTM
Phosphorylated on serine and threonine residues. Phosphorylated on Thr-1648 by Rho-kinase. Its phosphorylation by Rho-kinase inhibits its guanine nucleotide exchange activity, its interaction with MAP1A, MAP1B, PARP1 and YWHAE and reduces its ability to promote neurite growth (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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