Mouse Anti-TIAM2 Recombinant Antibody (CBYJT-3115) (CBMAB-T2383-YJ)

Name: Mouse Anti-TIAM2 Recombinant Antibody (CBYJT-3115)
SKU: CBMAB-T2383-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-3115

Application

S-ELISA, ELISA, WB

Immunogen

TIAM2 (NP_001010927, 527 a.a. ~ 624 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.2

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 527-624

More Infomation

Target

Full Name

TIAM2 Gene(Protein Coding) T Cell Lymphoma Invasion And Metastasis 2

Introduction

TIAM2 is a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. TIAM2 may function in neural cell development.

Entrez Gene ID

26230

UniProt ID

Q8IVF5

Alternative Names

T Cell Lymphoma Invasion And Metastasis 2; T-Cell Lymphoma Invasion And Metastasis 2; SIF And TIAM1-Like Exchange Factor; TIAM-2; STEF; T-Lymphoma Invasion And Metastasis-Inducing Protein 2; KIAA2016

Function

Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity).
Activates specifically RAC1, but not CDC42 and RHOA.

Biological Process

Biological Process activation of GTPase activitySource:GO_Central1 Publication
Biological Process positive regulation of axonogenesisSource:GO_Central1 Publication
Biological Process regulation of small GTPase mediated signal transductionSource:Reactome
Biological Process small GTPase mediated signal transductionSource:GO_Central1 Publication

Cellular Location

Cytoplasm
Cell projection, lamellipodium
Cell projection, filopodium
Cell projection, growth cone
Cell projection, neuron projection
Perikaryon

PTM

Phosphorylated on serine and threonine residues. Phosphorylated on Thr-1648 by Rho-kinase. Its phosphorylation by Rho-kinase inhibits its guanine nucleotide exchange activity, its interaction with MAP1A, MAP1B, PARP1 and YWHAE and reduces its ability to promote neurite growth (By similarity).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

TIAM2 Matched Antibody Pair (1205) (CAT#: APMAB-1205LY)

Related Products

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Mouse Anti-TIAM2 Recombinant Antibody (1C10) (CAT#: CBMAB-A9091-LY)

TIAM2 Matched Antibody Pair (1205) (CAT#: APMAB-1205LY)

Mouse Anti-TIAM2 Recombinant Antibody (CBYJT-3114) (CAT#: CBMAB-T2382-YJ)

Mouse Anti-TIAM2 Recombinant Antibody (CBYJT-3117) (CAT#: CBMAB-T2385-YJ)

Mouse Anti-TIAM2 Recombinant Antibody (3C1) (CAT#: CBMAB-A9092-LY)

Rabbit Anti-TIAM2 Recombinant Antibody (CBYJT-3116) (CAT#: CBMAB-T2384-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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