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Mouse Anti-TIAM2 Recombinant Antibody (CBYJT-3114) (CBMAB-T2382-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TIAM2 (T Cell Lymphoma Invasion And Metastasis 2). The antibody can be used for immunoassay techniques, such as ELISA, IF, WB.
See all TIAM2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-3114
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa527-625 from human TIAM2 (NP_001010927) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 527-625

Target

Full Name
TIAM2 Gene(Protein Coding) T Cell Lymphoma Invasion And Metastasis 2
Introduction
TIAM2 is a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. TIAM2 may function in neural cell development.
Entrez Gene ID
26230
UniProt ID
Q8IVF5
Alternative Names
T Cell Lymphoma Invasion And Metastasis 2; T-Cell Lymphoma Invasion And Metastasis 2; SIF And TIAM1-Like Exchange Factor; TIAM-2; STEF; T-Lymphoma Invasion And Metastasis-Inducing Protein 2; KIAA2016
Function
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity).
Activates specifically RAC1, but not CDC42 and RHOA.
Biological Process
Biological Process activation of GTPase activitySource:GO_Central1 Publication
Biological Process positive regulation of axonogenesisSource:GO_Central1 Publication
Biological Process regulation of small GTPase mediated signal transductionSource:Reactome
Biological Process small GTPase mediated signal transductionSource:GO_Central1 Publication
Cellular Location
Cytoplasm
Cell projection, lamellipodium
Cell projection, filopodium
Cell projection, growth cone
Cell projection, neuron projection
Perikaryon
PTM
Phosphorylated on serine and threonine residues. Phosphorylated on Thr-1648 by Rho-kinase. Its phosphorylation by Rho-kinase inhibits its guanine nucleotide exchange activity, its interaction with MAP1A, MAP1B, PARP1 and YWHAE and reduces its ability to promote neurite growth (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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