TKT

This gene encodes a thiamine-dependent enzyme which plays a role in the channeling of excess sugar phosphates to glycolysis in the pentose phosphate pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]

Full Name

TKT Gene(Protein Coding) Transketolase

Function

Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.

Biological Process

Biological Process glyceraldehyde-3-phosphate biosynthetic processSource:UniProtKB1 Publication
Biological Process pentose-phosphate shuntSource:UniProtKB1 Publication
Biological Process pentose-phosphate shunt, non-oxidative branchSource:GO_Central1 Publication
Biological Process regulation of growthSource:Ensembl
Biological Process ribose phosphate biosynthetic processSource:GO_Central1 Publication

Cellular Location

cytosol
endoplasmic reticulum membrane
extracellular exosome
nuclear body
nucleoplasm
peroxisome
vesicle

Involvement in disease

Short stature, developmental delay, and congenital heart defects (SDDHD):
An autosomal recessive syndrome characterized by short stature, developmental delay, intellectual disability and congenital heart defects including ventricular septal defect, atrial septal defect and patent foramen ovale. Cataract and uveitis are observed in some patients.

Anti-TKT antibodies

Mouse Anti-TKT Recombinant Antibody (CBYJT-3273) (CBMAB-T2558-YJ)

Datasheet

SDS

Target: TKT

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-3273

Application*: WB, IP, P, F, IC, IF, E

Mouse Anti-TKT Recombinant Antibody (CBYJT-3272) (CBMAB-T2557-YJ)

Datasheet

SDS

Target: TKT

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-3272

Application*: F, IF, P, WB

Mouse Anti-TKT Recombinant Antibody (CBYJT-3274) (CBMAB-T2559-YJ)

Datasheet

SDS

Target: TKT

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse

Clone: CBYJT-3274

Application*: E, WB, IH, IF, F

Mouse Anti-TKT Recombinant Antibody (CBYJT-3275) (CBMAB-T2560-YJ)

Datasheet

SDS

Target: TKT

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: CBYJT-3275

Application*: E, WB, IH, F

Mouse Anti-TKT Recombinant Antibody (16-3C1) (CBMAB-0041-CN)

Datasheet

SDS

Target: TKT

Host: Mouse

Antibody Isotype: IgG1

Specificity: Frog

Clone: 16-3C1

Application*: IH, WB

Mouse Anti-TKT Recombinant Antibody (37-1B2) (CBMAB-0155-CN)

Datasheet

SDS

Target: TKT

Host: Mouse

Antibody Isotype: IgG1

Specificity: Frog

Clone: 37-1B2

Application*: E

Mouse Anti-TKT Recombinant Antibody (CF439) (CBMAB-FT083LY)

Datasheet

SDS

Target: TKT

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: CF439

Application*: ELISA, WB, IHC, FC

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)