TLE3

This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]
Full Name
TLE3 Transducin Like Enhancer Of Split 3
Function
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).
Biological Process
Biological Process animal organ morphogenesisSource:ProtInc1 Publication
Biological Process negative regulation of canonical Wnt signaling pathwaySource:GO_Central1 Publication
Biological Process negative regulation of cold-induced thermogenesisSource:YuBioLabBy Similarity
Biological Process signal transductionSource:ProtInc1 Publication
Biological Process Wnt signaling pathwaySource:UniProtKB-KW
Cellular Location
Nucleus
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Anti-TLE3 antibodies

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Mouse Anti-Tle3 Recombinant Antibody (CBYJT-3298) (CBMAB-T2585-YJ)

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Target: TLE3
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBYJT-3298
Application*: WB, IP, IF, P, E
Datasheet SDS

Mouse Anti-TLE3 Recombinant Antibody (CBYJT-3297) (CBMAB-T2584-YJ)

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Target: TLE3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3297
Application*: E, WB, IH, IP
Datasheet SDS

Mouse Anti-TLE3 Recombinant Antibody (CBYJT-3296) (CBMAB-T2583-YJ)

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Target: TLE3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3296
Application*: IH, WB
Datasheet SDS

Mouse Anti-TLE3 Recombinant Antibody (CF441) (CBMAB-FT092LY)

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Target: TLE3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF441
Application*: ELISA, WB, IHC, IP
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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