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Mouse Anti-TLE3 Recombinant Antibody (CBYJT-3296) (CBMAB-T2583-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TLE3 (Transducin Like Enhancer Of Split 3). The antibody can be used for immunoassay techniques, such as IHC, WB.
See all TLE3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-3296
Antibody Isotype
IgG1
Application
IHC, WB

Basic Information

Immunogen
Recombinant protein corresponding to Human TLE3
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2, 40% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TLE3 Transducin Like Enhancer Of Split 3
Introduction
TLE3 is a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of TLE3 has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma.
Entrez Gene ID
7090
UniProt ID
Q04726
Alternative Names
Transducin Like Enhancer Of Split 3; Transducin-Like Enhancer Of Split 3 (E(Sp1) Homolog, Drosophila); Enhancer Of Split Groucho-Like Protein 3; ESG3; Transducin-Like Enhancer Of Split 3, Homolog Of Drosophila E(Sp1); Transducin-Like Enhancer Of Split 3 Short Isoform; Transducin-Like Enhancer Protein 3
Function
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).
Biological Process
Biological Process animal organ morphogenesisSource:ProtInc1 Publication
Biological Process negative regulation of canonical Wnt signaling pathwaySource:GO_Central1 Publication
Biological Process negative regulation of cold-induced thermogenesisSource:YuBioLabBy Similarity
Biological Process signal transductionSource:ProtInc1 Publication
Biological Process Wnt signaling pathwaySource:UniProtKB-KW
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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