TLK2

The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.[supplied by OMIM

tousled-like kinase 2

Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A and ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy.

Biological Process cell cycleSource:UniProtKB-KW
Biological Process cellular response to DNA damage stimulusSource:UniProtKB1 Publication
Biological Process cellular response to gamma radiationSource:UniProtKB1 Publication
Biological Process chromatin organizationSource:UniProtKB-KW
Biological Process chromosome segregationSource:UniProtKB1 Publication
Biological Process intracellular signal transductionSource:UniProtKB1 Publication
Biological Process localizationSource:DisProt1 Publication
Biological Process negative regulation of autophagySource:BHF-UCL1 Publication
Biological Process negative regulation of proteasomal ubiquitin-dependent protein catabolic processSource:UniProtKB1 Publication
Biological Process peptidyl-serine phosphorylationSource:UniProtKB1 Publication
Biological Process protein phosphorylationSource:UniProtKB1 Publication
Biological Process regulation of chromatin organizationSource:UniProtKB1 Publication

Nucleus
Cytoplasm, perinuclear region
Cytoplasm, cytoskeleton
Colocalizes with the cytoplasmic intermediate filament system during the G1 phase of the cell cycle. Present in the perinuclear region at S phase and in the nucleus at late G2.

Intellectual developmental disorder, autosomal dominant 57 (MRD57):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD57 is characterized by delayed psychomotor development apparent in infancy or early childhood, and a variety of behavioral abnormalities. Affected individuals may have severe gastro-intestinal problems, and facial dysmorphism.

Phosphorylated at Ser-750, probably by CHEK1.