TLK2

The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.[supplied by OMIM
Full Name
tousled-like kinase 2
Function
Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A and ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy.
Biological Process
Biological Process cell cycleSource:UniProtKB-KW
Biological Process cellular response to DNA damage stimulusSource:UniProtKB1 Publication
Biological Process cellular response to gamma radiationSource:UniProtKB1 Publication
Biological Process chromatin organizationSource:UniProtKB-KW
Biological Process chromosome segregationSource:UniProtKB1 Publication
Biological Process intracellular signal transductionSource:UniProtKB1 Publication
Biological Process localizationSource:DisProt1 Publication
Biological Process negative regulation of autophagySource:BHF-UCL1 Publication
Biological Process negative regulation of proteasomal ubiquitin-dependent protein catabolic processSource:UniProtKB1 Publication
Biological Process peptidyl-serine phosphorylationSource:UniProtKB1 Publication
Biological Process protein phosphorylationSource:UniProtKB1 Publication
Biological Process regulation of chromatin organizationSource:UniProtKB1 Publication
Cellular Location
Nucleus
Cytoplasm, perinuclear region
Cytoplasm, cytoskeleton
Colocalizes with the cytoplasmic intermediate filament system during the G1 phase of the cell cycle. Present in the perinuclear region at S phase and in the nucleus at late G2.
Involvement in disease
Intellectual developmental disorder, autosomal dominant 57 (MRD57):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD57 is characterized by delayed psychomotor development apparent in infancy or early childhood, and a variety of behavioral abnormalities. Affected individuals may have severe gastro-intestinal problems, and facial dysmorphism.
PTM
Phosphorylated at Ser-750, probably by CHEK1.
View more

Anti-TLK2 antibodies

+ Filters
Loading...

Mouse Anti-TLK2 Recombinant Antibody (2G7) (CBMAB-A9134-LY)

Go to compareCompare
Target: TLK2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2G7
Application*: WB, E
Datasheet SDS

Mouse Anti-TLK2 Recombinant Antibody (CBYJT-3315) (CBMAB-T2603-YJ)

Go to compareCompare
Target: TLK2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-3315
Application*: SE, E, WB, IF, P
Datasheet SDS

Mouse Anti-TLK2 Recombinant Antibody (CBYJT-3314) (CBMAB-T2602-YJ)

Go to compareCompare
Target: TLK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3314
Application*: P, WB
Datasheet SDS

Mouse Anti-TLK2 Recombinant Antibody (CBYJT-3313) (CBMAB-T2601-YJ)

Go to compareCompare
Target: TLK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3313
Application*: IH
Datasheet SDS

Mouse Anti-TLK2 Recombinant Antibody (CBYJT-3312) (CBMAB-T2600-YJ)

Go to compareCompare
Target: TLK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3312
Application*: IH
Datasheet SDS

Mouse Anti-TLK2 Recombinant Antibody (CBYJT-3311) (CBMAB-T2599-YJ)

Go to compareCompare
Target: TLK2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-3311
Application*: E, IF, IH, WB
Datasheet SDS

Mouse Anti-TLK2 Recombinant Antibody (CBYJT-3310) (CBMAB-T2598-YJ)

Go to compareCompare
Target: TLK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3310
Application*: WB, IH
Datasheet SDS

Mouse Anti-TLK2 Recombinant Antibody (CBYJT-3309) (CBMAB-T2597-YJ)

Go to compareCompare
Target: TLK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3309
Application*: WB, IH
Datasheet SDS

Mouse Anti-TLK2 Recombinant Antibody (CBYJT-3308) (CBMAB-T2596-YJ)

Go to compareCompare
Target: TLK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3308
Application*: WB
Datasheet SDS

Mouse Anti-TLK2 Recombinant Antibody (CBYJT-3307) (CBMAB-T2595-YJ)

Go to compareCompare
Target: TLK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3307
Application*: IH
Datasheet SDS

Mouse Anti-TLK2 Recombinant Antibody (CBYJT-3306) (CBMAB-T2594-YJ)

Go to compareCompare
Target: TLK2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-3306
Application*: WB, IH
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Hot products

For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
online inquiry
Online Inquiry