Human Recombinant TLK2 protein, GST Tag (V2LY-0526-LY7265)

Name: Human Recombinant TLK2 protein, GST Tag
SKU: V2LY-0526-LY7265
Rating: 5 (1 reviews)

See all TLK2 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant TLK2 protein, GST Tag consist of Amino Acid: 397-772 and predicts a molecular mass of 71.3 kDa.

Molecule Mass

71.3 kDa

Sequence

Amino Acid: 397-772

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

tousled-like kinase 2

Function

Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A and ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy.

Biological Process

Biological Process cell cycleSource:UniProtKB-KW
Biological Process cellular response to DNA damage stimulusSource:UniProtKB1 Publication
Biological Process cellular response to gamma radiationSource:UniProtKB1 Publication
Biological Process chromatin organizationSource:UniProtKB-KW
Biological Process chromosome segregationSource:UniProtKB1 Publication
Biological Process intracellular signal transductionSource:UniProtKB1 Publication
Biological Process localizationSource:DisProt1 Publication
Biological Process negative regulation of autophagySource:BHF-UCL1 Publication
Biological Process negative regulation of proteasomal ubiquitin-dependent protein catabolic processSource:UniProtKB1 Publication
Biological Process peptidyl-serine phosphorylationSource:UniProtKB1 Publication
Biological Process protein phosphorylationSource:UniProtKB1 Publication
Biological Process regulation of chromatin organizationSource:UniProtKB1 Publication

Cellular Location

Nucleus
Cytoplasm, perinuclear region
Cytoplasm, cytoskeleton
Colocalizes with the cytoplasmic intermediate filament system during the G1 phase of the cell cycle. Present in the perinuclear region at S phase and in the nucleus at late G2.

Involvement in disease

Intellectual developmental disorder, autosomal dominant 57 (MRD57):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD57 is characterized by delayed psychomotor development apparent in infancy or early childhood, and a variety of behavioral abnormalities. Affected individuals may have severe gastro-intestinal problems, and facial dysmorphism.

PTM

Phosphorylated at Ser-750, probably by CHEK1.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Human Recombinant TLK2 protein, GST Tag?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant TLK2 protein (CAT#: V2LY-0526-LY7264)

Human Recombinant TLK2, Active protein, GST Tag (CAT#: V2LY-0526-LY7266)

Related Products

Mouse Anti-TLK2 Recombinant Antibody (CBYJT-3313) (CAT#: CBMAB-T2601-YJ)

Mouse Anti-TLK2 Recombinant Antibody (CBYJT-3312) (CAT#: CBMAB-T2600-YJ)

Human Recombinant TLK2, Active protein, GST Tag (CAT#: V2LY-0526-LY7266)

Mouse Anti-TLK2 Recombinant Antibody (2G7) (CAT#: CBMAB-A9134-LY)

Human Recombinant TLK2 protein (CAT#: V2LY-0526-LY7264)

Mouse Anti-TLK2 Recombinant Antibody (CBYJT-3310) (CAT#: CBMAB-T2598-YJ)

Mouse Anti-TLK2 Recombinant Antibody (CBYJT-3311) (CAT#: CBMAB-T2599-YJ)

Mouse Anti-TLK2 Recombinant Antibody (CBYJT-3306) (CAT#: CBMAB-T2594-YJ)

Mouse Anti-TLK2 Recombinant Antibody (CBYJT-3315) (CAT#: CBMAB-T2603-YJ)

Mouse Anti-TLK2 Recombinant Antibody (CBYJT-3314) (CAT#: CBMAB-T2602-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry