Sign in or Register   Sign in or Register
  |  

Mouse Anti-TLK2 Recombinant Antibody (CBYJT-3307) (CBMAB-T2595-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TLK2 (Tousled Like Kinase 2). The antibody can be used for immunoassay techniques, such as IHC.
See all TLK2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-3307
Antibody Isotype
IgG1
Application
IHC

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 1-296 of human TLK2(NP_006843) produced in E. coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-296

Target

Full Name
tousled-like kinase 2
Introduction
TLK2 is a nuclear serine/threonine kinase that was first identified in Arabidopsis. TLK2 is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4 chaperone. TLK2 is associated with double-strand break repair of DNA damage caused by radiation.
Entrez Gene ID
11011
UniProt ID
Q86UE8
Alternative Names
Tousled Like Kinase 2; Tousled-Like Kinase 2; EC 2.7.11.1; PKU-ALPHA; HsHPK; Serine/Threonine-Protein Kinase Tousled-Like 2; EC 2.7.11
Function
Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A and ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy.
Biological Process
Biological Process cell cycleSource:UniProtKB-KW
Biological Process cellular response to DNA damage stimulusSource:UniProtKB1 Publication
Biological Process cellular response to gamma radiationSource:UniProtKB1 Publication
Biological Process chromatin organizationSource:UniProtKB-KW
Biological Process chromosome segregationSource:UniProtKB1 Publication
Biological Process intracellular signal transductionSource:UniProtKB1 Publication
Biological Process localizationSource:DisProt1 Publication
Biological Process negative regulation of autophagySource:BHF-UCL1 Publication
Biological Process negative regulation of proteasomal ubiquitin-dependent protein catabolic processSource:UniProtKB1 Publication
Biological Process peptidyl-serine phosphorylationSource:UniProtKB1 Publication
Biological Process protein phosphorylationSource:UniProtKB1 Publication
Biological Process regulation of chromatin organizationSource:UniProtKB1 Publication
Cellular Location
Nucleus
Cytoplasm, perinuclear region
Cytoplasm, cytoskeleton
Colocalizes with the cytoplasmic intermediate filament system during the G1 phase of the cell cycle. Present in the perinuclear region at S phase and in the nucleus at late G2.
Involvement in disease
Intellectual developmental disorder, autosomal dominant 57 (MRD57):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD57 is characterized by delayed psychomotor development apparent in infancy or early childhood, and a variety of behavioral abnormalities. Affected individuals may have severe gastro-intestinal problems, and facial dysmorphism.
PTM
Phosphorylated at Ser-750, probably by CHEK1.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-TLK2 Recombinant Antibody (CBYJT-3307)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare