Mouse Anti-TLK2 Recombinant Antibody (CBYJT-3310) (CBMAB-T2598-YJ)

Name: Mouse Anti-TLK2 Recombinant Antibody (CBYJT-3310)
SKU: CBMAB-T2598-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-3310

Application

WB, IHC

Immunogen

Human recombinant protein fragment corresponding to amino acids 1-296 of human TLK2 (NP_006843) produced in E. coli

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.3, 1% BSA, 50% Glycerol

Preservative

0.02% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 1-296

More Infomation

Target

Full Name

tousled-like kinase 2

Introduction

TLK2 is a nuclear serine/threonine kinase that was first identified in Arabidopsis. TLK2 is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4 chaperone. TLK2 is associated with double-strand break repair of DNA damage caused by radiation.

Entrez Gene ID

11011

UniProt ID

Q86UE8

Alternative Names

Tousled Like Kinase 2; Tousled-Like Kinase 2; EC 2.7.11.1; PKU-ALPHA; HsHPK; Serine/Threonine-Protein Kinase Tousled-Like 2; EC 2.7.11

Function

Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A and ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy.

Biological Process

Biological Process cell cycleSource:UniProtKB-KW
Biological Process cellular response to DNA damage stimulusSource:UniProtKB1 Publication
Biological Process cellular response to gamma radiationSource:UniProtKB1 Publication
Biological Process chromatin organizationSource:UniProtKB-KW
Biological Process chromosome segregationSource:UniProtKB1 Publication
Biological Process intracellular signal transductionSource:UniProtKB1 Publication
Biological Process localizationSource:DisProt1 Publication
Biological Process negative regulation of autophagySource:BHF-UCL1 Publication
Biological Process negative regulation of proteasomal ubiquitin-dependent protein catabolic processSource:UniProtKB1 Publication
Biological Process peptidyl-serine phosphorylationSource:UniProtKB1 Publication
Biological Process protein phosphorylationSource:UniProtKB1 Publication
Biological Process regulation of chromatin organizationSource:UniProtKB1 Publication

Cellular Location

Nucleus
Cytoplasm, perinuclear region
Cytoplasm, cytoskeleton
Colocalizes with the cytoplasmic intermediate filament system during the G1 phase of the cell cycle. Present in the perinuclear region at S phase and in the nucleus at late G2.

Involvement in disease

Intellectual developmental disorder, autosomal dominant 57 (MRD57):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD57 is characterized by delayed psychomotor development apparent in infancy or early childhood, and a variety of behavioral abnormalities. Affected individuals may have severe gastro-intestinal problems, and facial dysmorphism.

PTM

Phosphorylated at Ser-750, probably by CHEK1.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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