TMBIM6

TMBIM6P (Transmembrane BAX Inhibitor Motif Containing 7, Pseudogene) is a Pseudogene.

Full Name

Transmembrane BAX Inhibitor Motif Containing 6

Function

Suppressor of apoptosis (PubMed:21075086).
Modulates unfolded protein response signaling (PubMed:21075086).
Modulates ER calcium homeostasis by acting as a calcium-leak channel (PubMed:22128171).
Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (By similarity).

Biological Process

Biological Process autophagySource:UniProtKB-KW
Biological Process cellular response to unfolded proteinSource:ParkinsonsUK-UCL1 Publication
Biological Process endoplasmic reticulum calcium ion homeostasisSource:Ensembl
Biological Process negative regulation of apoptotic processSource:ParkinsonsUK-UCL1 Publication
Biological Process negative regulation of apoptotic signaling pathwaySource:ParkinsonsUK-UCL1 Publication
Biological Process negative regulation of calcium ion transport into cytosolSource:MGI1 Publication
Biological Process negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwaySource:ParkinsonsUK-UCL1 Publication
Biological Process negative regulation of endoribonuclease activitySource:ParkinsonsUK-UCL1 Publication
Biological Process negative regulation of hypoxia-induced intrinsic apoptotic signaling pathwaySource:ParkinsonsUK-UCL1 Publication
Biological Process negative regulation of immunoglobulin productionSource:Ensembl
Biological Process negative regulation of protein bindingSource:ParkinsonsUK-UCL1 Publication
Biological Process negative regulation of RNA splicingSource:ParkinsonsUK-UCL1 Publication
Biological Process negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stressSource:Ensembl
Biological Process neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressSource:Ensembl
Biological Process response to L-glutamateSource:ParkinsonsUK-UCL1 Publication

Cellular Location

Endoplasmic reticulum membrane

Topology

Cytoplasmic: 1-29
Helical: 30-50
Lumenal: 51-52
Helical: 53-73
Cytoplasmic: 74-86
Helical: 87-107
Lumenal: 108-112
Helical: 113-133
Cytoplasmic: 134-139
Helical: 140-160
Lumenal: 161-166
Helical: 167-187
Cytoplasmic: 188-206
Helical: 207-227
Cytoplasmic: 228-237