TMX3

TMX3 is a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The canonical protein encoded by TMX3 has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and a C-terminal ER-retention sequence. TMX3 is expressed in many tissues but has its highest expression in heart and skeletal muscle. It is expressed in the retinal neuroepithelium and lens epithelium in the developing murine eye and haploinsufficiency of TMX3 in humans and zebrafish is associated with microphthalmia.

Thioredoxin Related Transmembrane Protein 3

Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase.

Peptidyl-cysteine oxidation

Endoplasmic reticulum membrane

Lumenal: 25-375
Helical: 376-396
Cytoplasmic: 397-454

N-glycosylated.