TNFSF13
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. Other transcripts that skip the last exon of the upstream gene (TNFSF12) and continue with the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq]
Full Name
tumor necrosis factor (ligand) superfamily, member 13
Function
Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.
Biological Process
Biological Process immune response Source:InterPro
Biological Process positive regulation of cell population proliferation Source:ProtInc1 Publication
Biological Process positive regulation of isotype switching to IgA isotypes Source:MGI1 Publication
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process positive regulation of cell population proliferation Source:ProtInc1 Publication
Biological Process positive regulation of isotype switching to IgA isotypes Source:MGI1 Publication
Biological Process signal transduction Source:ProtInc1 Publication
Cellular Location
Secreted
PTM
The precursor is cleaved by furin.
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Anti-TNFSF13 antibodies
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CompareTarget: TNFSF13
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBYJT-3934
Application*: E, IC, F
Target: TNFSF13
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBYJT-3933
Application*: IC, F
Target: TNFSF13
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-3932
Application*: E, WB
Target: TNFSF13
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3931
Application*: WB, IC, F
Target: TNFSF13
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3930
Application*: F, IP, WB
Target: TNFSF13
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYJT-3929
Application*: WB
Target: TNFSF13
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-3928
Application*: E, WB
Target: TNFSF13
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYJT-3927
Application*: WB
Target: TNFSF13
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: Sacha-2
Application*: F, E, IC, IF
Target: TNFSF13
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: Sacha-1
Application*: F, IC, IF, IH
Target: TNFSF13
Host: Mouse
Antibody Isotype: IgG2b, λ
Specificity: Mouse
Clone: Apry-1-1
Application*: E, IP
Target: TNFSF13
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: Aprily-8
Application*: F, IC, IH, IP, WB
Target: TNFSF13
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: Aprily-5
Application*: E, IP, WB
Target: TNFSF13
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: Aprily-1
Application*: WB, IP, F
Target: TNFSF13
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: 6D129
Application*: E, F, IC
Target: TNFSF13
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6D126
Application*: F, IC, IH, IP, WB
Target: TNFSF13
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 33H5
Application*: E
Target: TNFSF13
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT4398
Application*: F
Target: TNFSF13
Host: Armenian Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBWJC-4548
Application*: IS, E
Target: TNFSF13
Host: Human
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBXC-0820
Application*: F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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