TNS1

The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms.
Full Name
TNS1
Function
Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton.
Biological Process
Biological Process fibroblast migration Source:GO_Central1 Publication
Cellular Location
Cell surface
Cell junction, focal adhesion
Cytoplasm, cytoskeleton
Localized at cell periphery preferentially to fibrillar adhesions than focal adhesions. Translocates from the cell edge to cell center in an ITGB1BP1-dependent manner.
PTM
Rapidly cleaved by calpain II.
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Anti-TNS1 antibodies

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Mouse Anti-TNS1 Antibody (1G8) (CBMAB-1657CQ)

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Target: TNS1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 1G8
Application*: E, M
Datasheet SDS

Mouse Anti-TNS1 Antibody (14C6) (CBMAB-1656CQ)

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Target: TNS1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 14C6
Application*: E, M
Datasheet SDS

Mouse Anti-TNS1 Antibody (13D10) (CBMAB-1655CQ)

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Target: TNS1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 13D10
Application*: E, M
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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